{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:58:58Z","timestamp":1755226738596,"version":"3.43.0"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to compare placenta\u2010related complications (adverse placental syndrome) between different types of fetal CHD based on cardiac hemodynamics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>All CHD cases diagnosed prenatally by fetal ECHO during 2009\u20132023 were selected. Exclusion criteria were as follows: multiple pregnancies, pregnancy termination, known genetic aberrations, and extracardiac anomalies. Cases were categorized into 6 groups based on theorized hemodynamic factors. Reference values for fetal growth restriction (FGR), preeclampsia (PE), pregnancy induced hypertension (PIH), and intra uterine fetal demise (IUFD) from the overall Dutch and\/or European population were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After exclusion, 1293 cases were available for analysis. The incidence of FGR was 198\/1247 (15.9%). There was a significant difference in FGR between the groups of CHD (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) though it could not be correlated with aortic flow and oxygenation. There was a high incidence of PE (64\/1282, 5.0%), PIH (43\/1284, 3.3%), and IUFD (33\/1291, 2.6%) in our cohort as compared to reference values. Nonetheless, there were no differences in PE, PIH, and IUFD between the different CHD groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A high incidence of adverse placental syndrome was found though this could not be related to fetal hemodynamics. Even in CHDs without hemodynamic changes, a high incidence of these complications was found. This might be a clinical manifestation of early embryological developmental pathways that affect both the placenta and the fetal heart.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6819","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T23:28:43Z","timestamp":1748302123000},"page":"1122-1129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pregnancy Complications in Fetal Congenital Heart Disease: A Result of Common Early Developmental Pathways Rather Than Fetal Hemodynamics"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7327-1915","authenticated-orcid":false,"given":"Maartje C.","family":"Snoep","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damla","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine Amsterdam University Medical Center  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anouk M. C.","family":"Roestenburg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Pajkrt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine Amsterdam University Medical Center  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine Amsterdam University Medical Center  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingeborg H.","family":"Linskens","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine Amsterdam University Medical Center  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingmar","family":"Knobbe","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Amsterdam University Medical Center  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally\u2010Ann","family":"Clur","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Amsterdam University Medical Center  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lieke","family":"Rozendaal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lotte E.","family":"van der Meeren","sequence":"additional","affiliation":[{"name":"Department of Pathology Leiden University Medical Center  Leiden the Netherlands"},{"name":"Department of Pathology Erasmus Medical Center  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique C.","family":"Haak","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine Leiden University Medical Center  Leiden the 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