{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:43:28Z","timestamp":1784346208860,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate differences in diffusion tensor imaging (DTI) parameters in the brain between fetuses with congenital diaphragmatic hernia (CDH) and age\u2010matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This retrospective IRB\u2010approved study included fetal MRIs for CDH and gestational age (GA) matched controls with lung pathology other than CDH with normal fetal brains. Fetal DTI data were acquired in 15 noncollinear diffusion\u2010weighting directions with the b\u2010value at 600\u00a0s\/mm<jats:sup>2<\/jats:sup> (1 b0). Slice\u2010to\u2010volume registration (SVR) was employed to correct for motion artifact.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010eight controls (27.3\u00a0\u00b1\u00a04.1\u00a0weeks\u00a0GA) and 26 CDH (28.1\u00a0\u00b1\u00a04.2\u00a0weeks\u00a0GA) fetuses were included. Fractional anisotropy (FA) values were significantly higher (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) in CDH fetuses relative to controls in 12 of 50 white matter (WM) regions examined based on ANCOVA controlling for GA. After controlling for GA, sex, and CDH side, FA values in the CDH fetuses had a significant positive correlation with observed\u2010to\u2010expected lung volumes in 20 of 50 WM regions and with percent predicted lung volumes in 29 of 50 WM regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data demonstrate evidence of microstructural differences based on DTI indices in the brain between CDH fetuses and age\u2010matched controls along with correlation with the degree of pulmonary hypoplasia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6835","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T22:30:42Z","timestamp":1749681042000},"page":"1045-1052","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diffusion Tensor Imaging of Fetuses With Congenital Diaphragmatic Hernia"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8251-7481","authenticated-orcid":false,"given":"Usha D.","family":"Nagaraj","sequence":"first","affiliation":[{"name":"Department of Radiology and Medical Imaging Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Dudley","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital\u2014Imaging Research Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3872-9027","authenticated-orcid":false,"given":"Beth M.","family":"Kline\u2010Fath","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L.","family":"Merhar","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine  Cincinnati Ohio USA"},{"name":"Division of Neonatology Cincinnati Children's Hospital Medical Center Perinatal Institute  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco T.","family":"Mangano","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine  Cincinnati Ohio USA"},{"name":"Department of 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