{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:18:46Z","timestamp":1782184726432,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate changes in fetal lung size\/volume and intrapulmonary circulation after serial amnioinfusions (AMI) in fetuses with early anhydramnios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten fetuses with anhydramnios due to renal agenesis (<jats:italic>n<\/jats:italic>\u00a0=\u00a04) or renal dysplasia (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) were treated with serial AMIs. Before AMI, the following ultrasound parameters were obtained: fetal lung area, total lung volume (TLV), O\/E LHR, thorax circumference (TC), cardiothoracic ratio (CTR), and pulsatility index of the main intrapulmonary artery (IPA). Differences in lung biometrics between the first and last AMIs are reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred thirty\u2010nine (median <jats:italic>n<\/jats:italic>\u00a0=\u00a014, [7\u201322] per patient) AMIs were performed. All deliveries were at \u2265\u00a029 + 6\u00a0weeks\/days of gestation. There were increases in lung areas (Left (z\u2010scores (z\u2010sc)) \u22121.86\/\u22120.35; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, Right \u22122.09\/\u22120.81; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002), and in O\/E LHRs (Left 0.56\/0.73; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04, Right 0.57\/0.73; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.009). TLV increased (z\u2010sc 0.24\/0.53; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.7) and IPA decreased (z\u2010sc 0.87\/0.43; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.051), but differences were not significant. No differences in TC (z\u2010sc 0.57\/0.56; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.97) or CTR (0.58\/0.58; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.1) were documented. The distribution of all lung biometric parameters across pregnancy showed values below the expected mean for gestational age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fetuses with early anhydramnios treated with serial amnioinfusions showed an increase in lung size; however, this increment was below the expected mean for gestational age.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6839","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T02:08:38Z","timestamp":1750730918000},"page":"1167-1175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lung Growth and Intrapulmonary Circulation in Fetuses With Anhydramnios Due to Severe Renal Anomalies Treated With Serial Amnioinfusions"],"prefix":"10.1002","volume":"45","author":[{"given":"Edgar","family":"Hernandez\u2010Andrade","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology and Reproductive Sciences Division of Fetal Intervention Health Science Center at Houston John P. and Katherine G. McGovern Medical School The University of Texas  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Gerulewicz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Reproductive Sciences Division of Fetal Intervention Health Science Center at Houston John P. and Katherine G. McGovern Medical School The University of Texas  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerrie","family":"Refuerzo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Reproductive Sciences Division of Fetal Intervention Health Science Center at Houston John P. and Katherine G. McGovern Medical School The University of Texas  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KuoJen","family":"Tsao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Health Science Center at Houston John P. and Katherine G. McGovern Medical School The University of Texas  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne M.","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Health Science Center at Houston John P. and Katherine G. McGovern Medical School The University of Texas  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Swinford","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Health Science Center at Houston John P. and Katherine G. McGovern Medical School The University of Texas  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3666-9593","authenticated-orcid":false,"given":"Percy","family":"Pacora","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Reproductive Sciences Division of Fetal Intervention Health Science Center at Houston John P. and Katherine G. McGovern Medical School The University of Texas  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6276-854X","authenticated-orcid":false,"given":"Eric","family":"Bergh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Reproductive Sciences Division of Fetal Intervention Health Science Center at Houston John P. and Katherine G. McGovern Medical School The University of Texas  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Health Science Center at Houston John P. and Katherine G. McGovern Medical School The University of Texas  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3801-346X","authenticated-orcid":false,"given":"Ramesha","family":"Papanna","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Reproductive Sciences Division of Fetal Intervention Health Science Center at Houston John P. and Katherine G. McGovern Medical School The University of Texas  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9830-2212","authenticated-orcid":false,"given":"Jimmy","family":"Espinoza","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Reproductive Sciences Division of Fetal Intervention Health Science Center at Houston John P. and Katherine G. McGovern Medical School The University of Texas  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Reproductive Sciences Division of Fetal Intervention Health Science Center at Houston John P. and Katherine G. McGovern Medical School The University of Texas  Houston Texas USA"},{"name":"Department of Pediatric Surgery Health Science Center at Houston John P. and Katherine G. 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