{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:45:23Z","timestamp":1785329123131,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess parental preferences, expectations and understanding of genome\u2010wide cell\u2010free DNA screening (gwNIPT) in Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A cross\u2010sectional survey study utilizing an anonymous electronic questionnaire was conducted across three participating screening services in Australia between September 2023 and November 2024. Questions pertained to respondent demographics, pre\u2010screening counselling, and accuracy expectations of gwNIPT for various chromosomal anomalies. Statistical analyses to investigate associations between responses used Chi\u2010squared and Fisher's exact tests, ordinal logistic regression, and the Kruskal\u2010Wallis test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 329 survey responses recorded, of which 216 were completed (65.7%). The most frequent source of NIPT referral was a medical doctor (74.1%), and the most common duration of pre\u2010screening counselling was 5\u00a0minutes (41.0%). Respondents showed overwhelming interest in all anomalies included in gwNIPT as well as various phenotypic outcomes including those of uncertain clinical significance. Despite this, only a minority of patients were aware that they were undergoing genome\u2010wide screening (38.2%), and respondents did not anticipate a statistically significant difference in screening accuracy across different anomaly types (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.715).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Respondents undergoing gwNIPT indicated a preference to receive as much genetic information about their pregnancies as possible. Pre\u2010screening counselling should therefore include the limitations of gwNIPT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6842","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T21:33:45Z","timestamp":1750368825000},"page":"994-1003","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Patient Preferences and Understanding of Genome\u2010Wide Cell\u2010Free DNA Screening for Foetal Chromosomal Imbalances: A Survey Study"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8197-7996","authenticated-orcid":false,"given":"Yvette","family":"Raymond","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Monash University  Clayton Australia"},{"name":"Monash Women's Monash Health  Clayton Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shavi","family":"Fernando","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Monash University  Clayton Australia"},{"name":"Monash Women's Monash Health  Clayton Australia"},{"name":"Monash Obstetrics  Clayton Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben W.","family":"Mol","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Monash University  Clayton Australia"},{"name":"Monash Women's Monash Health  Clayton Australia"},{"name":"Aberdeen Centre for Women's Health Research University of Aberdeen  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melody","family":"Menezes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The University of Melbourne  Melbourne Australia"},{"name":"Victorian Clinical Genetic Services Ltd  Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8979-4534","authenticated-orcid":false,"given":"Andrew","family":"McLennan","sequence":"additional","affiliation":[{"name":"Discipline of Obstetrics Gynaecology and Neonatology The University of Sydney  Sydney Australia"},{"name":"Sydney Ultrasound for Women  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Meagher","sequence":"additional","affiliation":[{"name":"Monash Ultrasound for Women  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Hill","sequence":"additional","affiliation":[{"name":"Repromed Dulwich Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Rolnik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Monash University  Clayton Australia"},{"name":"Monash Women's Monash Health  Clayton Australia"},{"name":"Monash Ultrasound for Women  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2016.03.009"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14791"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17283"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.08.034"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471\u20100528.17386"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2022.100844"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6233"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3871"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.01.009"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13841"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010genom\u2010083118\u2010015053"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010024\u201006565\u20101"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010020\u201003279\u2010y"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4941"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010023\u201001504\u20108"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738\u20103991(03)00207\u20106"},{"key":"e_1_2_10_18_1","article-title":"Determining Sample Size; 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