{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:32:27Z","timestamp":1788370347289,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T00:00:00Z","timestamp":1751155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to assess outcomes of fetuses with prenatally detected omphalocele and the frequency of successful vaginal delivery in pregnancies with suspected non\u2010lethal omphalocele and intended active neonatal management and its impact on neonatal outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Prenatally diagnosed omphalocele cases in Amsterdam UMC from January 2007 to January 2023 were selected. Ultrasound data including the omphalocele circumference\/abdominal circumference (OC\/AC) ratio were collected and perinatal data were obtained for liveborn cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 225 cases were included, with a live birth rate of 20.0% (45\/225). Of the suspected non\u2010lethal cases with active neonatal management, vaginal delivery was pursued in 78.9% (30\/38), of which 76.7% (23\/30) succeeded. The rate of giant omphaloceles did not differ significantly between vaginal and caesarean deliveries, nor did the rate of nulliparity, maximum OC\/AC ratio, extracorporeal liver on prenatal ultrasound and successful primary closure. Intrapartum sac rupture occurred in 13.0% (3\/23) of successful vaginal deliveries, which was not associated with the OC\/AC ratio and in none of the cases with cesarean section. Birth dystocia of the abdomen occurred in none of the cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In cases of intended vaginal delivery, 76.7% of vaginal deliveries succeeded, even in cases with giant omphalocele, of which the majority did not experience perinatal complications. Therefore, vaginal delivery appears to be a feasible option in cases with prenatally diagnosed omphaloceles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.6843","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:14:12Z","timestamp":1751242452000},"page":"1689-1697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Vaginal Delivery in Cases of Prenatally Diagnosed Omphalocele: Feasibility and Outcomes"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3595-4598","authenticated-orcid":false,"given":"H.","family":"Heinrich","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam UMC Location University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Kunne","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam UMC Location University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. P. M.","family":"Derikx","sequence":"additional","affiliation":[{"name":"Amsterdam Reproduction and Development  Amsterdam the Netherlands"},{"name":"Department of Pediatric Surgery Amsterdam UMC Location University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism Research Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam UMC Location University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. H.","family":"Linskens","sequence":"additional","affiliation":[{"name":"Amsterdam Reproduction and Development  Amsterdam the Netherlands"},{"name":"Department of Obstetrics and Gynecology Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Pajkrt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam UMC Location University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2022.07.004"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2013.10.003"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097\u20100223(199706)17:6<511::aid\u2010pd102>3.3.co;2\u2010p"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5886"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323326"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.04.015"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383\u2010018\u20104265\u2010x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3959"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201088245\u20100"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100031\u20101276737"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6135"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1978"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.106852"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0301\u20102115(98)00170\u20105"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250\u2010200111000\u201000029"},{"issue":"3","key":"e_1_2_11_17_1","first-page":"395","article-title":"Fetal Gastroschisis: A Preliminary Report Advocating the Use of Cesarean Section","volume":"67","author":"Lenke R. 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