{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T06:04:57Z","timestamp":1785045897567,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Serial amnioinfusion therapy (SAT) has emerged as a potential mitigatory intervention to adverse perinatal outcomes associated with congenital bilateral renal agenesis (BRA). However, its efficacy, safety, and ethical implications warrant thorough evaluation. This systematic review, developed according to PRISMA guidelines, analyzes the published data on outcomes of SAT for BRA and explores its implications. Inclusion criteria were a diagnosis of bilateral renal agenesis, therapeutic use of amnioinfusion, amnioinfusion procedure, and individual maternal and fetal outcome reports. A total of 192 published studies were identified. Among these, 11 full texts were included (<jats:italic>N<\/jats:italic>\u00a0=\u00a040). Only cases resulting in live birth and with reported maternal and neonatal outcomes were analyzed. The average number of amnioinfusions per mother was 9 (<jats:italic>n<\/jats:italic>\u00a0=\u00a023; range 1\u201326 infusions). Median gestational age at delivery was 33.4\u00a0weeks (<jats:italic>n<\/jats:italic>\u00a0=\u00a040; range 23.7\u201336.8\u00a0weeks). APGAR scores (<jats:italic>n<\/jats:italic>\u00a0=\u00a014) at 1 and 5\u00a0min were 4 and 6, respectively. Almost half of newborns died within 33\u00a0days of life (<jats:italic>n<\/jats:italic>\u00a0=\u00a019) and 7 (17.5%) survived at the time of original publication. Overall neonatal mortality was 82.5% (33 of 40). These findings suggest that SAT for BRA improves the chances of neonatal survival in the first few days to weeks of life but not consistently beyond that time. Additional advances in neonatal care are needed to improve long\u2010term outcomes in peripartum survivors.<\/jats:p>","DOI":"10.1002\/pd.6850","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T03:48:41Z","timestamp":1752896921000},"page":"1182-1191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serial Amnioinfusion Therapy for Treatment of Congenital Bilateral Renal Agenesis\u2014A Systematic Review"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5652-3623","authenticated-orcid":false,"given":"Adriana","family":"Baez","sequence":"first","affiliation":[{"name":"Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2620-7486","authenticated-orcid":false,"given":"Gabriele","family":"Tonni","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Neonatology, and, Researcher Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda USL Reggio Emilia  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8872-1165","authenticated-orcid":false,"given":"Chryso P.","family":"Katsoufis","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology Department of Pediatrics University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2473-643X","authenticated-orcid":false,"given":"Amanda","family":"Alladin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Department of Pediatrics University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7370-5122","authenticated-orcid":false,"given":"Ugo Maria","family":"Pierucci","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery \u201cV. Buzzi\u201d Children\u2019s Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yair J.","family":"Blumenfeld","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine and Obstetrics Department of Obstetrics &amp; Gynecology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3642-5858","authenticated-orcid":false,"given":"Rodrigo","family":"Ruano","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine Department of Obstetrics, Gynecology &amp; Reproductive Sciences University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2024.102780l"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20103476(46)80241\u20105l"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.21153l"},{"key":"e_1_2_11_5_1","first-page":"411","volume-title":"A Cautionary Note on New Fetal Interventions","author":"Johnson A.","year":"2014"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103468(82)80476\u20104"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000002416l"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/circoutcomes.122.009638"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000497472l"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109378(85)80116\u20102"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20100528.2005.00544.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1028\u20104559(08)60009\u20101"},{"key":"e_1_2_11_13_1","volume-title":"The Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta\u2010Analyses","author":"Wells G. 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