{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:12:09Z","timestamp":1783041129506,"version":"3.54.6"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the association between the introduction of the fetal anomaly scans in the Netherlands and termination of pregnancy (TOP) in cases of prenatally detected upper limb anomalies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective study among prenatally detected upper limb anomalies between 2000 and 2023. Anomalies were categorized as reduction defects, syndactyly, or polydactyly, and classified as isolated or non\u2010isolated. We analyzed TOP rates across three periods (2000\u20132006, 2007\u2013August 2021, September 2021\u20132023), including an interrupted time series (ITS) analysis to assess the impact of introducing second\u2010 and first\u2010trimester anomaly scans (STAS, FTAS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 300 pregnancies, of which 133 (44.3%) were isolated. Overall TOP rates did not differ significantly between periods, except for isolated reduction defects, where a significant increase was observed (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.032). TOP rates over time did not increase for syndactyly and polydactyly. Median gestational age at diagnosis decreased across the three periods: from 20.4 to 19.4\u00a0weeks and then to 14.9\u00a0weeks. Similarly, the timing of termination of pregnancy decreased from 20.5 to 16.8 weeks and then to 15.0\u00a0weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Earlier prenatal detection followed the introduction of STAS and FTAS. Despite this shift in timing, no consistent changes in termination rates were observed across the study periods. While overall TOP rates remained stable, a trend towards higher termination rates was observed for isolated reduction defects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.6882","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T03:47:40Z","timestamp":1756784860000},"page":"1450-1458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Influence of the Introduction of Fetal Anomaly Scans on Pregnancy Terminations in Cases of Upper Limb Anomalies: A Retrospective Cohort Study From 2000 to 2023"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7157-6014","authenticated-orcid":false,"given":"Arda","family":"Ardu\u00e7","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline","family":"Huiberts","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margriet H. M.","family":"van Doesburg","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingeborg H.","family":"Linskens","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merel C. Van","family":"Maarle","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Pajkrt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"(NVOG) DSoOaG.Guideline Second Trimester Anomaly Scan Including Appendix Sonomarkers https:\/\/www.nvog.nl\/wp\u2010content\/uploads\/2023\/04\/230411\u2010Leidraad\u2010tweede\u2010trimester\u2010SEO_DEF\u2010incl\u2010bijlage\u2010sonomarkers\u2010v2.pdf."},{"key":"e_1_2_11_3_1","unstructured":"Care SoPHa.Pregnancy Screening: Participation in the 20\u2010Week Anomaly Scan https:\/\/www.staatvenz.nl\/kerncijfers\/zwangerschapsscreening\u201020\u2010weken\u2010echo\u2010deelname."},{"key":"e_1_2_11_4_1","unstructured":"Kwaliteitseisen eerste Trimester SEO (Structureel echoscopisch onderzoek).Versie 2.1 2022 NVOG. 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