{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T17:16:57Z","timestamp":1778174217651,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess hemodynamic changes in the third trimester by magnetic resonance imaging (MRI) in fetuses with major congenital heart defects (CHD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty fetuses with CHD and 23 healthy controls had consecutive MRI at 28, 32, and 38\u00a0weeks of gestation. Blood flow in the ascending aorta, main pulmonary artery, and umbilical vein was measured using phase contrast MRI and indexed to estimated fetal weight. Mixed effects models assessed weight\u2010indexed changes over time and between groups. CHD cases were further classified into left\u2010sided defects, right\u2010sided defects, or transposed great arteries for subgroup analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Combined ventricular output (CVO) decreased by 1.7% per week (95% CI 0.7%\u20132.7%) from 28 to 38\u00a0weeks in both fetuses with CHD and controls, with no difference between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.3). Umbilical vein (UV) flow decreased by 2.5% per week (95% CI 1.5%\u20133.5%) with no difference between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.7). CVO was correlated with UV flow (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.6, 95% CI 0.4\u20130.7). The aortic\u2010to\u2010pulmonary flow ratio remained constant in all subgroups. Left\u2010 and right\u2010sided defects were associated with increased flow across the contralateral side.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CVO decreased similarly in fetuses with CHD and controls during the third trimester, associated with reduced UV flow, reflecting a more efficient placenta toward term.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.6893","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T01:29:56Z","timestamp":1758763796000},"page":"1604-1614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal Magnetic Resonance Imaging Study of Hemodynamic Changes in the Third Trimester in Fetuses With Major Congenital Heart Defects and Healthy Fetuses"],"prefix":"10.1002","volume":"45","author":[{"given":"Signe G.","family":"Hellmuth","sequence":"first","affiliation":[{"name":"Center of Fetal Medicine Department of Gynecology, Fertility, and Obstetrics Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ditte S.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Center of Fetal Medicine Department of Gynecology, Fertility, and Obstetrics Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Wright","sequence":"additional","affiliation":[{"name":"University of Exeter  Exeter UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7475-513X","authenticated-orcid":false,"given":"Cathrine","family":"Vedel","sequence":"additional","affiliation":[{"name":"Center of Fetal Medicine Department of Gynecology, Fertility, and Obstetrics Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Genetics Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Tabor","sequence":"additional","affiliation":[{"name":"Center of Fetal Medicine Department of Gynecology, Fertility, and Obstetrics Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olav B.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Center of Fetal Medicine Department of Gynecology, Fertility, and Obstetrics Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Vejlstrup","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Heart Centre, Copenhagen University Hospital Rigshospitalet  Copenhagen 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