{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:03:45Z","timestamp":1780049025975,"version":"3.53.1"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNFSA170030576"],"award-info":[{"award-number":["NNFSA170030576"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine peak systolic velocity in the middle cerebral artery (MCA\u2010PSV) in fetuses with transposition of the great arteries (TGA) and evaluate if TGA is associated with fetal anemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A retrospective, exploratory study with inclusion of singleton fetuses born with TGA at Copenhagen University Hospital Rigshospitalet 2016\u20132023. Data on MCA\u2010PSV, neonatal hemoglobin and specific diagnoses were manually retrieved from patient files.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 52 cases, 205 MCA\u2010PSV measurements from GA 20\u00a0+\u00a00 to 39\u00a0+\u00a01 met the inclusion criteria. Overall median MCA\u2010PSV MoM was 1.09 (IQR 0.96; 1.20), increasing from 0.97 (IQR 0.86; 1.15) at gestational week 20\u00a0+\u00a00 to 24\u00a0+\u00a06 to 1.13 (IQR 0.95; 1.19) at gestational week 35\u00a0+\u00a00 to 39\u00a0+\u00a01. There were no differences in MCA\u2010PSV MoM between cases with and without surgical closure of a VSD. Median hemoglobin concentration was 16.4\u00a0g\/dL (IQR 15.3\u201317.2\u00a0g\/dL) and MCA\u2010PSV was inversely correlated with hemoglobin (\u22124.81 [95% confidence interval \u22127.21; \u22122.41]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study adds to the limited evidence on MCA\u2010PSV in TGA fetuses, supporting a trend of increasing MCA\u2010PSV MoM with gestational age, although not significant after accounting for multiple measurements. Higher MCA\u2010PSV MoM correlated with lower neonatal hemoglobin. However, findings do not show that TGA fetuses have elevated MCA\u2010PSV due to anemia or that VSD influences MCA\u2010PSV levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.6905","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T03:58:52Z","timestamp":1759204732000},"page":"1615-1620","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Middle Cerebral Artery Peak Systolic Velocity in Fetuses With Transposition of the Great Arteries"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5953-2453","authenticated-orcid":false,"given":"Ditte S.","family":"J\u00f8rgensen","sequence":"first","affiliation":[{"name":"Center of Fetal Medicine Department of Gynecology, Fertility, and Obstetrics Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte K.","family":"Ekelund","sequence":"additional","affiliation":[{"name":"Center of Fetal Medicine Department of Gynecology, Fertility, and Obstetrics Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone","family":"N\u00f8rgaard","sequence":"additional","affiliation":[{"name":"Center of Fetal Medicine Department of Gynecology, Fertility, and Obstetrics Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederikke H.","family":"Sander","sequence":"additional","affiliation":[{"name":"Center of Fetal Medicine Department of Gynecology, Fertility, and Obstetrics Copenhagen University Hospital Rigshospitalet  Copenhagen 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