{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T14:58:49Z","timestamp":1765378729735,"version":"3.46.0"},"reference-count":20,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n To evaluate the perinatal outcome of monochorionic pregnancies complicated by Twin Anemia\u2010Polycythemia Sequence (TAPS) and identify prognostic factors associated with adverse outcomes.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A retrospective study (2012\u20132024) analyzed TAPS cases at a tertiary center. Demographic, obstetric, and neonatal outcomes were compared between conservative management and interventions (intrauterine transfusion, laser surgery, or selective feticide). TAPS characteristics were also analyzed in three subgroups: deliveries before\/after 32\u00a0weeks, CNS findings on MRI, and dual versus single\/no survival.<\/jats:p>\n <\/jats:sec>\n \n Result<\/jats:title>\n \n Of 32 TAPS cases, 68.75% were spontaneous, and 31.25% followed TTTS laser treatment. Conservative management\u00a0was used in 62.5%, while 21.9% received intrauterine transfusions, 9.4% underwent laser treatment, and 9.4% had\u00a0selective feticide. Gestational age at diagnosis and delivery was earlier in the intervention group (25 vs. 27\u00a0weeks,\n p<\/jats:italic>\n \u00a0=\u00a00.05; 30.6 vs. 32.6\u00a0weeks,\n p<\/jats:italic>\n \u00a0=\u00a00.04). CNS abnormalities (25%) were linked to earlier diagnosis. Perinatal survival was 86%, with dual, single, and no survival rates of 78.1%, 15.6%, and 6.2%, respectively. Patients with single\/no survival were characterized by an earlier gestational age at diagnosis of TAPS compared to those with dual survival (21 vs. 27\u00a0weeks,\n p<\/jats:italic>\n \u00a0<\u00a00.01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Earlier TAPS diagnosis is associated with poorer outcomes, including reduced survival and increased risk of brain injury.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/pd.70003","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:49:46Z","timestamp":1761018586000},"page":"1737-1745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Adverse Perinatal Outcome in Twin Anemia Polycythemia Sequence: Evidence From a Single Center Cohort Study"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6365-3741","authenticated-orcid":false,"given":"Keren","family":"Zloto","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Fetal Medicine Unit Sheba Medical Center Ramat Gan Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noa","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medical and Health Sciences Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stav","family":"Cohen","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medical and Health Sciences Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagai","family":"Avnet","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Fetal Medicine Unit Sheba Medical Center Ramat Gan Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boaz","family":"Weisz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Fetal Medicine Unit Sheba Medical Center Ramat Gan Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoav","family":"Yinon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Fetal Medicine Unit Sheba Medical Center Ramat Gan Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6194"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22073"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20846"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(13)62419\u20108"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22042"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14925"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061759"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15821"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.08.069"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/FM9.0000000000000065"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20116"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000304512"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20096"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2453"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13382"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.07.041"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13387"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12337"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20846"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701\u20102163(15)30512\u20100"}],"container-title":["Prenatal 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