{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T15:27:41Z","timestamp":1781882861203,"version":"3.54.5"},"reference-count":13,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to characterize the fetal features across gestation and describe genotype\u2010phenotype correlations for pregnancies with fetal RASopathies that were more severely affected as they presented with at least one abnormal fluid collection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Retrospective cohort study of pregnancies with a fetal RASopathy and one or more abnormal fluid collections. Ultrasound and clinic databases were searched at six institutions to identify pathogenic or likely pathogenic variants indicating a fetal RASopathy. Phenotypic features were organized by gestational age to evaluate their evolution, and chi\u2010square and Fisher exact proportions were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010six pregnancies were included. Pleural effusions, skin edema, ascites, and cardiac abnormalities presented across gestation. Cystic hygroma and jugular sacs presented in the first trimester and persisted into the second trimester. Hepatomegaly, polyhydramnios, small or absent stomach, and contractures were more frequent in the second and third trimesters. Contractures were more likely with\n                      <jats:italic>HRAS<\/jats:italic>\n                      variants (63% vs. 24%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.044) and increased nuchal translucency or cystic hygroma were more common with\n                      <jats:italic>SOS1<\/jats:italic>\n                      variants (100% vs. 44%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.049).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These data provide insight into genotype\u2010phenotype correlations and the course of fetal RASopathies that present with at least one abnormal fluid collection. Timing of these phenotypes is important to consider for future research on targeted in utero approaches to management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70039","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T03:06:13Z","timestamp":1765249573000},"page":"892-903","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evolving Features of RASopathies Among Pregnancies With Abnormal Fetal Fluid Collections"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9257-2273","authenticated-orcid":false,"given":"Natalie B.","family":"Gulrajani","sequence":"first","affiliation":[{"name":"School of Medicine University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Boscardin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billie R.","family":"Lianoglou","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California  San Francisco California USA"},{"name":"Center for Maternal\u2010Fetal Precision Medicine University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Tick","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, &amp; Reproductive Sciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7200-4540","authenticated-orcid":false,"given":"Carmen M. A.","family":"Santoli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, &amp; Reproductive Sciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-3850","authenticated-orcid":false,"given":"Kristen A.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Division of Maternal Fetal Medicine John Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1792-4029","authenticated-orcid":false,"given":"Angie C.","family":"Jelin","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Division of Maternal Fetal Medicine John Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3638-036X","authenticated-orcid":false,"given":"Lorraine","family":"Dugoff","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Giardine","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cori","family":"Feist","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Oregon Health and Sciences University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4491-1335","authenticated-orcid":false,"given":"Rachel","family":"Pilliod","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Oregon Health and Sciences University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Dukhovny","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Oregon Health and Sciences University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Gilmore","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeta L.","family":"Vora","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisling","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0736-9199","authenticated-orcid":false,"given":"Peter N.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health at Charit\u00e9  Berlin Germany"},{"name":"The Jackson Laboratory for Genomic Medicine  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Norton","sequence":"additional","affiliation":[{"name":"Center for Maternal\u2010Fetal Precision Medicine University of California  San Francisco California USA"},{"name":"Department of Obstetrics, Gynecology, &amp; 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