{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T20:31:19Z","timestamp":1769027479665,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to identify prenatal ultrasonographic predictors of enteral feeding tolerance in neonates with omphaloceles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This retrospective cohort study included all live\u2010born neonates prenatally diagnosed with omphalocele at Emma Children's Hospital\/Amsterdam UMC approximately 2004\u20132024. Prenatal ultrasonographic data included fetal ascites, omphalocele circumference\/abdominal circumference (OC\/AC) ratio, extracorporeal liver, polyhydramnios and associated structural anomalies. Associations with enteral feeding tolerance, measured by duration of parenteral nutrition (PN) and time to achieve full enteral feeds (FEF), and the need for tube feeding post\u2010admission were analyzed using linear and logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010two neonates were included (42.9% male). Median time to FEF was 10.0\u00a0days (IQR\u00a0=\u00a05.8\u201314.5) and median PN duration 5.0\u00a0days (IQR\u00a0=\u00a00.0\u201310.5). At discharge, 28.6% required full or partial nasogastric tube feeding. Polyhydramnios was excluded due to low prevalence (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01). Fetal ascites predicted longer PN duration (ratio 4.05, 95% CI [1.57, 10.60]) and tube feeding post\u2010admission (OR 9.27, 95% CI [1.47, 58.40]). A higher OC\/AC ratio predicted a longer time to FEF (ratio 4.39, 95% CI [1.54, 12.69]). No associations were found for extracorporeal liver or associated structural anomalies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fetal ascites and a higher OC\/AC ratio were predictive of delayed enteral feeding tolerance. While full enteral feeds were achieved within 2\u00a0weeks, 29% required tube feeding after discharge.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70050","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T14:59:33Z","timestamp":1765378773000},"page":"21-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Can Prenatal Ultrasonographic Markers Predict Enteral Feeding Tolerance in Neonates With Fetal Omphalocele?"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6624-921X","authenticated-orcid":false,"given":"Maaike","family":"Hogerwerf","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Amsterdam Pediatric Abdominal Center Emma Children's Hospital Amsterdam UMC University of Amsterdam and Vrije Universiteit Amsterdam  Amsterdam the Netherlands"},{"name":"Department of Pediatric Gastroenterology and Nutrition Amsterdam Pediatric Abdominal Center Emma Children's Hospital Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development Research Institute University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism Research Institute University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3595-4598","authenticated-orcid":false,"given":"Hanna","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Amsterdam Reproduction and Development Research Institute University of Amsterdam  Amsterdam the Netherlands"},{"name":"Department of Obstetrics and Gynecology Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merit M.","family":"Tabbers","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition Amsterdam Pediatric Abdominal Center Emma Children's Hospital Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development Research Institute University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism Research Institute University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon R.","family":"Gorter","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Amsterdam Pediatric Abdominal Center Emma Children's Hospital Amsterdam UMC University of Amsterdam and Vrije Universiteit Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development Research Institute University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism Research Institute University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart G. P.","family":"Koot","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition Amsterdam Pediatric Abdominal Center Emma Children's Hospital Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development Research Institute University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism Research Institute University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos W. R.","family":"Twisk","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Data Science Amsterdam UMC Vrije Universiteit Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Pajkrt","sequence":"additional","affiliation":[{"name":"Amsterdam Reproduction and Development Research Institute University of Amsterdam  Amsterdam the Netherlands"},{"name":"Department of Obstetrics and Gynecology Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joep P. M.","family":"Derikx","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Amsterdam Pediatric Abdominal Center Emma Children's Hospital Amsterdam UMC University of Amsterdam and Vrije Universiteit Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development Research Institute University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism Research Institute University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1607"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383\u2010021\u201004978\u2010z"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5886"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2019.04.007"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323326"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1978"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.04.015"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/children8020170"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1028\u20104559(07)60002\u20103"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1028\u20104559(07)60003\u20105"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2018.10.047"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/mpg.0000000000001463"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100042\u20101757360"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2023.04.005"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.10.010"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355936"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.06.007"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.06.032"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372\u2010019\u20100410\u20101"},{"key":"e_1_2_12_21_1","unstructured":"RIVM. \u201cPre\u2010 En Neonatale Screeningen (PNS): NIPT En SEO Voor Professionals \u201d (2025): Accessed May 1 2025 https:\/\/www.pns.nl\/professionals\/nipt\u2010seo."},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000004605"},{"issue":"6","key":"e_1_2_12_23_1","first-page":"989","article-title":"Quantifiable Polyhydramnios: Diagnosis and Management","volume":"75","author":"Carlson D. E.","year":"1990","journal-title":"Obstetrics & Gynecology"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.07.016"},{"key":"e_1_2_12_25_1","unstructured":"M.van Stuivenberg J. G.de Roest C. J.Boomgaard\u2010Beijert et\u00a0al. \u201cLandelijke Aanbeveling Buikwanddefecten: Nederlandse Vereniging Voor Kindergeneeskunde \u201d (2019): Accessed August 18 2025 https:\/\/www.nvk.nl\/kennisdocument\/n3\u2010aanbeveling\u2010buikwanddefecten\/."},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000070801"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm\u20102014\u20100326"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100036\u20101597269"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4102"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7698"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383\u2010018\u20104265\u2010x"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.70050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.70050","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.70050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T04:42:59Z","timestamp":1768970579000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.70050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,10]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/pd.70050"],"URL":"https:\/\/doi.org\/10.1002\/pd.70050","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,10]]},"assertion":[{"value":"2025-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}