{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:54:25Z","timestamp":1790434465245,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether invasive genetic testing should be systematically proposed in cases of FGR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Descriptive retrospective study of 159 FGR cases (defined by an estimated fetal growth &lt; 3rd percentile, regardless of Doppler findings) managed at the Toulouse Fetal Medicine Center (TFMC) during 2022\u20132023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean gestational age at diagnosis was 23.7\u00a0weeks. Head circumference &lt; 3rd percentile was observed in 35% of cases, hemodynamic signs in 57%, and oligohydramnios in 11%. Invasive testing was performed in 56% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a089) of cases, with a diagnostic yield in cases with hemodynamic signs of 19% for genetic syndromes (whether chromosomal or monogenic), which dropped to 11% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a08) in isolated FGR. Postnatally, 50% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a067) of cases were attributed to placental causes, 31% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a041) to genetic disorders (of which 41% had a negative prenatal genetic workup), while 13% remained unexplained. Placental causes were most often due to chronic maternal vascular malperfusion (72%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Findings support the systematic offer of exome sequencing in second\u2010trimester FGR, regardless of whether it is isolated, associated with head circumference &lt; 3rd percentile, or with abnormal hemodynamic profiles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70064","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T01:33:59Z","timestamp":1768181639000},"page":"832-841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Moderate Diagnostic Yield of Exome Sequencing in Fetal Growth Restriction: Retrospective Insights"],"prefix":"10.1002","volume":"46","author":[{"given":"Maud","family":"Langeois","sequence":"first","affiliation":[{"name":"Department of Medical Genetics Toulouse University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Paret","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Paule de Viguier Hospital Toulouse University Hospital  Toulouse France"},{"name":"CERPOP UMR 1295 Team SPHERE (Study of Perinatal, Pediatric and Adolescent Health: Epidemiological Research and Evaluation) Toulouse III University  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Aziza","sequence":"additional","affiliation":[{"name":"Anatomy and Pathological Cytology Department Fetal Pathology Unit CHU Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2662-4351","authenticated-orcid":false,"given":"Paul","family":"Guerby","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Paule de Viguier Hospital Toulouse University Hospital  Toulouse France"},{"name":"CERPOP UMR 1295 Team SPHERE (Study of Perinatal, Pediatric and Adolescent Health: Epidemiological Research and Evaluation) Toulouse III University  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Vayssi\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Paule de Viguier Hospital Toulouse University Hospital  Toulouse France"},{"name":"CERPOP UMR 1295 Team SPHERE (Study of Perinatal, Pediatric and Adolescent Health: Epidemiological Research and Evaluation) Toulouse III University  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Dubucs","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Toulouse University Hospital  Toulouse France"},{"name":"CERPOP UMR 1295 Team SPHERE (Study of Perinatal, Pediatric and Adolescent Health: Epidemiological Research and Evaluation) Toulouse III University  Toulouse France"},{"name":"Anatomy and Pathological Cytology Department Fetal Pathology Unit CHU Toulouse  Toulouse 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