{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:14:12Z","timestamp":1775805252850,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Current inclusion criteria for fetal surgery at most centers include the absence of multiple major anomalies and a normal chromosome analysis or fluorescence in situ hybridization (FISH) for aneuploidy. We evaluated the concordance of FISH with non\u2010invasive screening methodologies to determine if invasive genetic testing provides additional information on fetal surgery candidacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective chart review was performed on 963 pregnancies evaluated for fetal surgery at the Cincinnati Children's Hospital Fetal Care Center between July 1, 2018 and July 31, 2023 for genetic testing results, fetal imaging, and surgical candidacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      FISH was concordant with screening results in 100% of pregnancies whose imaging and cell\u2010free fetal DNA screening suggested a fetus at low risk for trisomy 21, trisomy 18, trisomy 13, and sex chromosome aneuploidies. Pregnancies with multiple congenital anomalies were significantly more likely to have abnormal genetic testing compared to pregnancies with isolated anomalies (52% vs. 17%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this study cohort, FISH did not provide additional information for the risk\u2010benefit analysis of fetal surgery and introduced additional risk to the pregnancy due to the need for invasive fetal DNA collection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70068","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T17:05:57Z","timestamp":1768410357000},"page":"306-312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utility of Fluorescence In Situ Hybridization as a Fetal Surgery Eligibility Criterion for Isolated Congenital Anomalies When Non\u2010Invasive Screening Is Performed"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3229-7169","authenticated-orcid":false,"given":"Ethan","family":"Lorence","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Human Genetics of the College of Medicine at the University of Cincinnati  Cincinnati Ohio USA"},{"name":"Department of Human Genetics at the Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Precision Medicine Institute at TriHealth  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8204-7667","authenticated-orcid":false,"given":"Katelyn","family":"Seither","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Fetal Care Center  Cincinnati Ohio USA"},{"name":"Cincinnati Children's Hospital Medical Center Division of Neonatology and Pulmonary Biology  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Human Genetics of the College of Medicine at the University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3523-1935","authenticated-orcid":false,"given":"Kara B.","family":"Markham","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Fetal Care Center  Cincinnati Ohio USA"},{"name":"Department of Obstetrics and Gynecology University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrix","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Human Genetics of the College of Medicine at the University of Cincinnati  Cincinnati Ohio USA"},{"name":"Department of Human Genetics at the Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Cincinnati Children's Fetal Care Center  Cincinnati Ohio 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