{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:03:12Z","timestamp":1783051392540,"version":"3.54.6"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We sought to perform multi\u2010variable modeling to assess the independent value of the CVPS in fetuses with Ebstein anomaly or tricuspid valve dysplasia (EA\/TVD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>CVPS was assessed at a core lab using the first and last echocardiograms during gestation. A receiver operating characteristic (ROC) curve analysis was conducted. Changes in the CVPS from the first to the last echo were assessed with Wilcoxon signed\u2010rank tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 164 fetuses with EA\/TVD with complete CVPS at the first echo. Nearly half, 48.8% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a080), had intrauterine fetal demise (IUFD) or died neonatally. At the first echo, median gestational age (GA) was 27.6\u00a0weeks (IQR: 23.0\u201331.0) and median CVPS was 7 (IQR: 6\u20138). The optimal cut\u2010point for classification of perinatal survival was observed at CVPS \u2265 6.5 (Youden index\u00a0=\u00a00.46). After adjustment, there remained a significant independent association between every 1\u2010point increase in the CVPS at first echo and the odds of perinatal survival (adjusted odds ratio: 2.0, 95% CI: 1.3 to 3.2, and\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003). The CVPS at the last echo decreased by a median of 1 point among both survivors (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01) and non\u2010survivors (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among fetuses with EA\/TVD, the CVPS may be used as an additional tool to assess perinatal survival throughout gestation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70071","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T07:21:06Z","timestamp":1768375266000},"page":"210-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cardiovascular Profile Score and Perinatal Survival Among Fetuses With Ebstein\u2019s Anomaly or Tricuspid Valve Dysplasia: A Multi\u2010Center Retrospective Cohort Study"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5220-9832","authenticated-orcid":false,"given":"Grace","family":"Freire","sequence":"first","affiliation":[{"name":"Perinatal Cardiology All Children's Hospital Johns Hopkins Medicine  St Petersburg Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen","family":"Thieu","sequence":"additional","affiliation":[{"name":"Nemours Children's Hospital  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Escobar\u2010Diaz","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Sant Joan de Deu  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4516-3770","authenticated-orcid":false,"given":"Rukmini","family":"Komarlu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Division of Cardiology Cleveland Clinic Children's Hospital Lerner College of Medicine of Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Vernon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology Seattle Children's Hospital University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Ikemba","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology Children's Medical Center University of Texas Southwestern Medical School  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik C.","family":"Michelfelder","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology Children's Healthcare of Atlanta Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus","family":"Samai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology Children's Healthcare of Atlanta Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Kovalchin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology Nationwide Children's Hospital Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8422-2158","authenticated-orcid":false,"given":"Wayne","family":"Tworetzky","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston's Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Huhta","sequence":"additional","affiliation":[{"name":"Perinatal Cardiology St. Joseph Hospital  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Wilhm","sequence":"additional","affiliation":[{"name":"Perinatal Cardiology All Children's Hospital Johns Hopkins Medicine  St Petersburg Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie L.","family":"Fierstein","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Translational Research Epidemiology and Biostatistics Shared Resource Johns Hopkins All Children's Hospital  St. Petersburg Florida USA"},{"name":"Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay R.","family":"Freud","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology The Hospital for Sick Children  Toronto Ontario 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