{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T23:38:14Z","timestamp":1775000294180,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically review perinatally accessible body fluid biomarkers of gastroschisis and those associated with disease severity or postnatal morbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      PubMed, Embase, Web of Science, Scopus, Cochrane CENTRAL,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      , and the International Clinical Trials Registry Platform were searched\u00a0for studies reporting body fluid biomarkers obtained from women carrying a fetus or neonates with gastroschisis. The primary aim was to identify biomarkers indicating gastroschisis; secondary aims included identifying biomarkers associated with disease severity (simple vs. complex) or postnatal morbidity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010two studies were included, showing substantial heterogeneity in sampling timing, fluid type, and biomarkers assessed. Among 13 studies reporting prenatal biomarkers, amniotic fluid total protein, IL\u20108, and ferritin differentiated fetuses with gastroschisis from normal fetuses. Total protein correlated with disease severity. Bile acid findings were inconsistent. Increased cord blood IL\u20108 at delivery was associated with the presence of gastroschisis and prolonged parenteral nutrition. Neonatal urinary intestinal fatty acid\u2010binding protein indicated the presence and severity of gastroschisis. An individual patient data\u00a0meta\u2010analysis of three studies identified four inflammatory cord blood biomarkers (IL\u20108, CXCL10, IL\u20104, and CX3CL1) associated with prolonged parenteral nutrition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Several perinatally accessible biomarkers are associated with gastroschisis, and some further correlate with severity or postnatal morbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70084","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T02:47:13Z","timestamp":1769827633000},"page":"348-359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Perinatally Accessible Biomarkers of Complex Gastroschisis: Systematic Review and Individual Patient Data Meta\u2010Analysis"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8326-7864","authenticated-orcid":false,"given":"Tomohiro","family":"Arai","sequence":"first","affiliation":[{"name":"Department of Development and Regeneration My FetUZ Fetal Research Center Cluster Woman and Child, Biomedical Sciences KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3050-373X","authenticated-orcid":false,"given":"Wasinee","family":"Tianthong","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration My FetUZ Fetal Research Center Cluster Woman and Child, Biomedical Sciences KU Leuven  Leuven Belgium"},{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5029-7899","authenticated-orcid":false,"given":"Francesca Maria","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration My FetUZ Fetal Research Center Cluster Woman and Child, Biomedical Sciences KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7331-6354","authenticated-orcid":false,"given":"Luc","family":"Joyeux","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration My FetUZ Fetal Research Center Cluster Woman and Child, Biomedical Sciences KU Leuven  Leuven Belgium"},{"name":"Division of Pediatric Surgery, Michael E. DeBakey Department of Surgery Texas Children's Hospital (TCH) and Baylor College of Medicine (BCM)  Houston Texas USA"},{"name":"Department of Obstetrics and Gynecology Texas Children's Center for Translational Fetal Research Texas Children's Fetal Center Pavilion for Women TCH and BCM  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1659-0207","authenticated-orcid":false,"given":"Paolo","family":"De Coppi","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration My FetUZ Fetal Research Center Cluster Woman and Child, Biomedical Sciences KU Leuven  Leuven Belgium"},{"name":"Pediatric Surgery Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-945X","authenticated-orcid":false,"given":"Jan","family":"Deprest","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration My FetUZ Fetal Research Center Cluster Woman and Child, Biomedical Sciences KU Leuven  Leuven Belgium"},{"name":"Institute for Women's Health University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"EUROCAT. \u201cEUROCAT Guide 1.5. 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