{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:32:09Z","timestamp":1773315129502,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare the 30\u2010day outcomes of infants undergoing fetal versus postnatal repair of open spina bifida (OSB) who met the equivalent eligibility criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A retrospective study of consecutive patients who underwent OSB repair (2018\u20132022) by a consistent pediatric neurosurgical team. All met the MOMS trial fetal surgery criteria. Primary outcomes included cerebrospinal fluid (CSF) complications, motor function, wound complications and non\u2010neurosurgical neonatal complications within 30\u00a0days of birth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 109 myelomeningocele repairs (82 fetal and 27 postnatal), postnatal repairs had higher mean birthweight (3116.8 vs. 2477.8\u00a0g;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01) and gestational age at delivery (38\u00a0+\u00a01 vs. 34\u00a0+\u00a04\u00a0weeks\u00a0+\u00a0days;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). Neonates with fetal repair were less likely to require hydrocephalus treatment (9% vs. 56%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01) or have CSF leak (1% vs. 19%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). Wound infection (5.2% vs. 14.8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.10) and dehiscence (2.6% vs. 14.8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.09) rates were comparable. Respiratory distress syndrome was more frequent with fetal surgery (43% vs. 4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.004), although neonatal intensive care (NICU) admission (34% vs. 26%) and neonatal hospital stay were comparable (fetal repair: 15.2\u00a0days\u00a0\u00b1\u00a02.1 vs. postnatal repair: 14.8\u00a0days\u00a0\u00b1\u00a03.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.91).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Open fetal repair was associated with earlier delivery but with comparable NICU and hospital stay and lower hydrocephalus treatment rate at 1\u00a0month of age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70088","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T04:10:14Z","timestamp":1770869414000},"page":"424-432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Open Fetal Versus Postnatal Repair of Spina Bifida Aperta\u2014A Comparison of Neonatal Outcomes"],"prefix":"10.1002","volume":"46","author":[{"given":"Serena","family":"Banh","sequence":"first","affiliation":[{"name":"Department of Paediatric Neurosurgery Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"},{"name":"University College London Great Ormond Street Institute of Child Health  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amparo","family":"Saenz","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurosurgery Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"},{"name":"University College London Great Ormond Street Institute of Child Health  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8900-0317","authenticated-orcid":false,"given":"Sofia","family":"Mastrodima\u2010Polychroniou","sequence":"additional","affiliation":[{"name":"University College London Elizabeth Garrett Anderson Institute for Women's Health  London UK"},{"name":"University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adalina","family":"Sacco","sequence":"additional","affiliation":[{"name":"University College London Elizabeth Garrett Anderson Institute for Women's Health  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuella","family":"Bredaki","sequence":"additional","affiliation":[{"name":"University College London Elizabeth Garrett Anderson Institute for Women's Health  London UK"},{"name":"University College London Hospitals 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Development and Regeneration Cluster Woman and Child Group Biomedical Sciences KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna L.","family":"David","sequence":"additional","affiliation":[{"name":"University College London Elizabeth Garrett Anderson Institute for Women's Health  London UK"},{"name":"University College London Hospitals NHS Foundation Trust  London UK"},{"name":"Department of Development and Regeneration Cluster Woman and Child Group Biomedical Sciences KU Leuven  Leuven Belgium"},{"name":"NIHR University College London Hospitals Biomedical Research Centre  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-945X","authenticated-orcid":false,"given":"Jan","family":"Deprest","sequence":"additional","affiliation":[{"name":"University College London Elizabeth Garrett Anderson Institute for Women's Health  London UK"},{"name":"University College London Hospitals NHS 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