{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:31:53Z","timestamp":1773315113115,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The neurodevelopmental outcome of \u2018Cystic\u2019 malformations of the posterior fossa with marked opening of the fourth ventricle, such as Dandy Walker malformation (DWM) and large Blake's pouch cyst (BPC), is a major issue. This study aimed to refine relevant MRI criteria for distinguishing DWM from BPC and identify prognostic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Inclusion criteria were prenatal retrocerebellar fluid space diameter &gt;\u00a010\u00a0mm, marked opening of the fourth ventricle with a tegmento\u2010vermian angle (TVA)\u00a0&gt;\u00a040\u00b0, and postnatal follow\u2010up &gt; 2\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      27 patients were classified as follows: 6 DWM characterized by an overall upward orientation of the tentorium, an open tegmento\u2010tentorial angle (TTA\u00a0&gt;\u00a078\u00a0) and a high TVA (median 132\u00b0); 15 BPC with a normal downward orientation of the proximal part of the tentorium (TTA\u00a0&lt;\u00a068\u00b0) and distal upward displacement (median TVA 74\u00b0); 3 PHACE syndromes (Posterior\u00a0fossa abnormalities, Haemangioma, Arterial cerebrovascular anomalies, Cardiac defects, Eye anomalies) and 3 unclassified. Four prognostic factors were identified, (i) diagnosis: DWM (two deaths, three learning disabilities and one typical development (TD)) versus BPC (five learning disabilities [4\/5 with associated malformation or genetic defects] and 10 TD); (ii) associated versus isolated (36% vs. 87% TD); (iii) obstructive ventriculomegaly versus no hydraulic complications (20% vs. 91% TD); and (iv) the foetal TVA value and clinical outcome (correlation coefficient\u00a0=\u00a00.561,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.006).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70093","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T02:10:33Z","timestamp":1771639833000},"page":"315-328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prenatal Diagnosis and Neurodevelopmental Outcome of Children With Marked Opening of the Fourth Ventricle: Challenges and Pitfalls in MRI Diagnostic Criteria"],"prefix":"10.1002","volume":"46","author":[{"given":"L\u00e9a","family":"Schieffer","sequence":"first","affiliation":[{"name":"Service de Neurop\u00e9diatrie Hospices Civils de Lyon  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Garel","sequence":"additional","affiliation":[{"name":"Service de radiologie H\u00f4pital Armand\u2010Trousseau  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Guibaud","sequence":"additional","affiliation":[{"name":"Service de radiologie Hospices Civils de Lyon  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christelle","family":"Rougeot\u2010Jung","sequence":"additional","affiliation":[{"name":"Service de Neurop\u00e9diatrie Hospices Civils de Lyon  Lyon 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