{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:15:10Z","timestamp":1784042110107,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To characterize the prenatal sonographic features across different trimesters and genomic spectrum of\n                      <jats:italic>NONO<\/jats:italic>\n                      \u2010related X\u2010linked intellectual developmental disorder.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We analyzed two fetuses presenting with corpus callosum agenesis and rare cardiac anomalies using genome sequencing and exome sequencing. A systematic literature review was conducted to provide a comprehensive analysis of genotype\u2010phenotype correlations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two novel cases were reported in this study: one with a de novo 61.7 kb deletion affecting both\n                      <jats:italic>NONO<\/jats:italic>\n                      and\n                      <jats:italic>ITGB1BP2<\/jats:italic>\n                      , and\u00a0another with a de novo c.1093 C &gt; T(p.Arg365Ter), a recurrent variant reported in the literature. A total of 23 cases with\n                      <jats:italic>NONO<\/jats:italic>\n                      defects and prenatal phenotypes were identified, encompassing 19 distinct variant types. Large deletions and splicing variants accounted for approximately 32% (6\/19). Among all cases, 78% (18\/23) exhibited typical or concurrent brain abnormalities, such as corpus callosum agenesis, cardiac defects including left ventricular noncompaction (LVNC), or short long bones in the second trimester. Notably, 4% (1\/23) of cases were reported with isolated intrauterine growth restriction (IUGR), primarily identified in the third trimester.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Genome sequencing facilitates thorough identification of the genetic causes of NONO\u2010related syndrome. The recurrent variant p.Arg365Ter has been reported to cause variable cardiac abnormalities in different patients, suggesting that other genetic or non\u2010genetic factors may contribute to the cardiac manifestations in NONO\u2010related syndromes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70097","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T14:38:11Z","timestamp":1771425491000},"page":"914-923","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>NONO<\/i>\n                    \u2010Related Syndromic X\u2010Linked Developmental Disability 34: Further Clinical and Molecular Delineation in a Prenatal Cohort"],"prefix":"10.1002","volume":"46","author":[{"given":"Yilin","family":"Zhao","sequence":"first","affiliation":[{"name":"Reproductive Medicine Institute Xi'an People's Hospital (Xi'an Fourth Hospital)  Xi'an China"},{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zou","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal Fetal Medicine Department of Obstetrics Fetal Medicine Unit and Prenatal Diagnosis Center Shanghai First Maternity and Infant Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3523-7685","authenticated-orcid":false,"given":"Mengmeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok Ming","family":"Law","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR 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