{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T06:54:20Z","timestamp":1776495260991,"version":"3.51.2"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study evaluates the procedural characteristics, complications, and outcomes of intrauterine transfusion (IUT) for fetal anemia caused by parvovirus B19 infection during the 2023\u20132024 epidemic in Northwestern Europe.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This multicenter observational study included all fetuses undergoing IUT for proven parvovirus B19\u2010induced anemia at three tertiary fetal therapy centers in Northwestern Europe. Maternal, fetal, and procedural data were collected from electronic records. Technical challenges and complications were defined a priori. Primary outcomes were procedural characteristics and complications, prenatal neurological outcomes, and perinatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 93 IUTs were performed in 74 fetuses. Hydrops fetalis was present in 53%. Technical challenges occurred in 24% of procedures and complications in 18%. 59% of technical challenges and 65% of complications occurred in IUTs performed in hydropic fetuses. Intracranial hemorrhage (ICH) occurred in 10% of fetuses and was associated with lower preoperative hemoglobin (2.3\u00a0\u00b1\u00a00.6\u00a0g\/dL vs. 4.4\u00a0\u00b1\u00a02.2\u00a0g\/dL;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.006). Perinatal survival was significantly lower following IUTs with complications (64%) compared with uncomplicated procedures (91%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.013).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IUT for parvovirus B19\u2010related fetal anemia is technically demanding, with complication rates exceeding prior reports. Complications and challenges significantly reduce perinatal survival. These findings underscore the importance of centralizing care in high\u2010volume fetal medicine centers with experienced operators.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70107","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T06:26:13Z","timestamp":1776493573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intrauterine Transfusions in Fetuses Affected by Parvovirus B19: Complications, Challenges and Outcomes"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6598-8097","authenticated-orcid":false,"given":"Banu","family":"\u00d6zbakir","sequence":"first","affiliation":[{"name":"Division of Fetal Medicine Department of Obstetrics and Gynecology Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Van den Eede","sequence":"additional","affiliation":[{"name":"Division of Fetal Medicine Department of Obstetrics and Gynecology UZ Leuven KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lone N.","family":"N\u00f8rgaard","sequence":"additional","affiliation":[{"name":"Center of Fetal Medicine Department of Gynecology Fertility and Pregnancy Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7837-4684","authenticated-orcid":false,"given":"Roland","family":"Devlieger","sequence":"additional","affiliation":[{"name":"Division of Fetal Medicine Department of Obstetrics and Gynecology UZ Leuven KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Sundberg","sequence":"additional","affiliation":[{"name":"Center of Fetal Medicine Department of Gynecology Fertility and Pregnancy Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0443-1997","authenticated-orcid":false,"given":"Monique C.","family":"Haak","sequence":"additional","affiliation":[{"name":"Division of Fetal Medicine Department of Obstetrics and Gynecology Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Femke","family":"Slaghekke","sequence":"additional","affiliation":[{"name":"Division of Fetal Medicine Department of Obstetrics and Gynecology Leiden University Medical Centre  Leiden the 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