{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:07:08Z","timestamp":1773011228838,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["ICA\u2010CDRF\u20102017\u201003\u201053"],"award-info":[{"award-number":["ICA\u2010CDRF\u20102017\u201003\u201053"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR302390"],"award-info":[{"award-number":["NIHR302390"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR\u2010CDF\u20102017\u201010\u2010037"],"award-info":[{"award-number":["NIHR\u2010CDF\u20102017\u201010\u2010037"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR\u2010301322"],"award-info":[{"award-number":["NIHR\u2010301322"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022656","name":"Centre Hospitalier Universitaire de N\u00eemes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022656","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005261","name":"Centre Hospitalier R\u00e9gional Universitaire de Montpellier","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study demonstrates the central nervous system (CNS) abnormalities detected using fetal post\u2010mortem micro\u2010focus computed tomography (Micro\u2010CT), independent of whether the abnormality contributed to the main diagnosis or cause of death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 1200 whole body post\u2010mortem fetal Micro\u2010CT scans in an unselected consecutive cohort between 2017 and 2024. The following categories for CNS abnormalities were used: enlarged cerebral spinal fluid (CSF) spaces, midline abnormalities, neural tube defects, disorders of neuronal proliferation, neuronal migration, and hindbrain development, and other cranial and facial abnormalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 78 individual CNS abnormalities were identified in 62\/1200 (5.2%) fetuses. The most common CNS abnormalities were neural tube defects (18\/78; 23.1%), ventriculomegaly (16\/78; 20.5%), and intracranial hemorrhage (12\/78; 15.4%). CNS abnormalities were isolated findings in 27\/62 (44%) abnormal cases, and part of a wider spectrum of extra\u2010CNS abnormalities in 35\/62 (56%) of cases. The commonest extra\u2010CNS association was musculoskeletal (25\/59; 42%). Despite significant maceration causing reduced image quality in 408\/1200 (34%) cases, Micro\u2010CT gave diagnostic CNS imaging in all 792\/1200 (66%) fetuses with low, mild, or moderate maceration (score below 4).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Post\u2010mortem Micro\u2010CT imaging can identify a wide range of CNS abnormalities following pregnancy loss in early gestation fetuses, even in the presence of maceration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70109","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:29:00Z","timestamp":1773005340000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Yield of Post\u2010Mortem Fetal Micro\u2010CT for Central Nervous System Abnormalities"],"prefix":"10.1002","author":[{"given":"Ian C.","family":"Simcock","sequence":"first","affiliation":[{"name":"Great Ormond Street Hospital for Children Department of Radiology  London UK"},{"name":"University College London Great Ormond Street Institute of Child Health  London UK"},{"name":"NIHR Great Ormond Street Hospital Biomedical Research Centre  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Lamouroux","sequence":"additional","affiliation":[{"name":"N\u00eemes University Hospital Department of Obstetrics and Gynaecology  Nimes France"},{"name":"Montpellier University Hospital Department of Clinical Genetics  Montpellier France"},{"name":"CNRS and Charles Coulomb Laboratory, BNIF User Facility Imaging ICAR Research Team, LIRMM, CNRS\u2010UM, University of Montpellier  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan C.","family":"Shelmerdine","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children Department of Radiology  London UK"},{"name":"University College London Great Ormond Street Institute of Child Health  London UK"},{"name":"NIHR Great Ormond Street Hospital Biomedical Research Centre  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Ciaran","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"University College London Great Ormond Street Institute of Child Health  London UK"},{"name":"NIHR Great Ormond Street Hospital Biomedical Research Centre  London UK"},{"name":"Great Ormond Street Hospital for Children Department of Histopathology  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil J.","family":"Sebire","sequence":"additional","affiliation":[{"name":"University College London Great Ormond Street Institute of Child Health  London UK"},{"name":"NIHR Great Ormond Street Hospital Biomedical Research Centre  London UK"},{"name":"Great Ormond Street Hospital for Children Department of Histopathology  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1213-3516","authenticated-orcid":false,"given":"Owen J.","family":"Arthurs","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children 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