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The detection rates of pCNV among fetuses with various ultrasonographic anomalies were compared with those of fetuses with no identifiable anomalies. In addition, the associations between ultrasonographic anomalies and aneuploidies or pCNV were investigated using Fisher's exact test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The detection rates of aneuploidies and pCNV were 6.20% (825\/13,312) and 6.19% (824\/13,312), respectively, in fetuses with ultrasonographic anomalies. Fetal hydrops was the ultrasonographic anomaly with the highest diagnostic rate for aneuploidies, at 32.58% among all isolated groups, particularly when combined with cystic hygroma, for which the diagnostic rate was 61.04%. Ten types of isolated ultrasonographic anomalies showed significantly higher diagnostic rates of pCNV (3.90%\u20137.43%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05, odds ratio\u00a0=\u00a02.19\u20134.32). Furthermore, this study first reported an association between 3q25.2\u2010q29 duplication and abdominal wall defects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings expanded the phenotypic spectrum of certain pCNVs and highlighted phenotype\u2010specific differences in the diagnostic yield of LP\u2010GS, providing valuable reference information for genetic counseling in prenatal diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70114","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:27:04Z","timestamp":1773005224000},"page":"974-982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Low\u2010Pass Genome Sequencing Reveals Associations Between Chromosomal Aberrations and Ultrasonographic Anomalies in a Cohort of 19,452 Fetuses"],"prefix":"10.1002","volume":"46","author":[{"given":"Lijuan","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Obstetrics Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9802-0250","authenticated-orcid":false,"given":"Jiayu","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics &amp; Hunan Key Laboratory of Medical Genetics School of Life Sciences Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Bioinformatics Center &amp; National Clinical Research Centre for Geriatric Disorders &amp; Department of Geriatrics Xiangya Hospital Central South University  Changsha 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