{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:56:12Z","timestamp":1791381372071,"version":"4.3.3"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Over the past few decades, several thousand pregnancies following kidney transplantation have been monitored but few studies have reported on first\u2010trimester Down syndrome screening. This study aimed to assess the performance of such screening and its relationship with renal function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We retrieved data on 16 pregnancies after kidney transplantation and 30 controls matched for age, weight and gestational age. First\u2010trimester blood creatinine levels were systematically researched. Among other variables, multiples of the median (MoM) values for free\u2010\u03b2hCG, pregnancy\u2010associated plasma protein\u2010A (PAPP\u2010A), nuchal translucency were compared. After statistical review, we combined our cases group with that of a previous study to obtain a cohort of 27 post\u2010transplantation pregnancies to explore correlations between variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median values of f\u03b2\u2010hCG MoM of cases and controls were significantly different (2.02 vs. 0.92;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) whereas those of PAPP\u2010A and NT MoM were not. Screen positive rate (SPR) were respectively 44% and 17% (cut\u2010off 1\/1000). Linear regressions were observed for f\u03b2\u2010hCG MoM and creatinine, but not for PAPP\u2010A, in our initial case group (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.699,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.025) and the merged group (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.724,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We confirmed a specific profile for first\u2010trimester screening variables in first\u2010trimester post\u2010transplantation pregnancies and the impact of renal function, through creatinine levels, on SPR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70124","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:53:26Z","timestamp":1773906806000},"page":"993-999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["First\u2010Trimester Down Syndrome Screening in Renal\u2010Transplanted Pregnant Women: Blood Creatinine Levels Impact False\u2010Positive Rate"],"prefix":"10.1002","volume":"46","author":[{"given":"Cl\u00e9ment","family":"Burgy","sequence":"first","affiliation":[{"name":"Laboratoire de Biochimie Institut F\u00e9d\u00e9ratif de Biologie CHU de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Chanourdie","sequence":"additional","affiliation":[{"name":"Laboratoire de Biochimie Institut F\u00e9d\u00e9ratif de Biologie CHU de Toulouse  Toulouse 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Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2662-4351","authenticated-orcid":false,"given":"Paul","family":"Guerby","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie et Transplantation d'organes CHU de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Vayssiere","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie et Transplantation d'organes CHU de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2434-3441","authenticated-orcid":false,"given":"Safouane M.","family":"Hamdi","sequence":"additional","affiliation":[{"name":"Laboratoire de Biochimie Institut F\u00e9d\u00e9ratif de Biologie CHU de Toulouse  Toulouse France"},{"name":"Univ Toulouse, INSERM, CERPOP, BIOETHICS Universit\u00e9 Paul\u2010Sabatier  Toulouse 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