{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:53:52Z","timestamp":1790909632693,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objective of this study was to examine the concordance of results between mosaic pre\u2010implantation genetic testing for aneuploidy (PGT\u2010A) and diagnostic testing in resulting pregnancies conceived by IVF with PGT\u2010A.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study retrospectively provides analysis of 328 patients ascertained due to a mosaic PGT\u2010A finding and 25 with a discordant reported sex, studied prenatally, utilizing standard karyotype and\/or SNP microarray analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>None of the 328 mosaic PGT\u2010A findings were confirmed by the diagnostic prenatal studies with karyotype and\/or microarray analysis. Additionally, of the 298 prenatal microarray studies performed, five demonstrated pathogenic abnormalities (1.7%) that were unrelated to PGT\u2010A referral. Thirty\u2010four of these cases were also studied to determine if UPD occurred; all were biparental.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This work emphasizes the importance of PGT\u2010A follow\u2010up and demonstrates that the vast majority will have normal diagnostic results and only a small number will be confirmed using prenatal diagnostic analysis. This work also suggests the most efficient way to proceed with diagnostic follow\u2010up studies. Additionally, it shows the importance of fetal sex confirmation in all normal PGT\u2010A studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70132","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T05:13:27Z","timestamp":1774847607000},"page":"1151-1158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytogenetic and Microarray Analysis Follow\u2010Up of PGT\u2010A Mosaic and Sex Discrepant Embryos During Pregnancy: Absence of Confirmation and Follow\u2010Up Recommendations"],"prefix":"10.1002","volume":"46","author":[{"given":"Laura A.","family":"Kline","sequence":"first","affiliation":[{"name":"Center for Molecular Biology and Pathology Labcorp  Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa A.","family":"Nitibhon","sequence":"additional","affiliation":[{"name":"Genetics and Women's Health Labcorp  Westborough Massachusetts USA"},{"name":"Vitrolife Group  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Dyr","sequence":"additional","affiliation":[{"name":"Labcorp  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4464-8872","authenticated-orcid":false,"given":"Erica L.","family":"Soster","sequence":"additional","affiliation":[{"name":"Genetics and Women's Health Labcorp  Westborough Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Sussman","sequence":"additional","affiliation":[{"name":"Center for Molecular Biology and Pathology Labcorp  Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian J.","family":"Weinblatt","sequence":"additional","affiliation":[{"name":"Genetics and Women's Health Labcorp  Westborough Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0475-6844","authenticated-orcid":false,"given":"Stuart","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Center for Molecular Biology and Pathology Labcorp  Research Triangle Park North Carolina USA"},{"name":"FACMG Center for Molecular Biology and Pathology Labcorp  Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1429193"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2024.04.013"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.11.041"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2022.01.010"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010023\u201002936\u20103"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000004084"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deac063"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.02.044"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958\u2010020\u201000616\u2010w"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gim.2024.101275"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2015.05.010"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1055665620954751"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC\u201024\u20100111"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.62104"},{"key":"e_1_2_12_16_1","unstructured":"How Common Is Infertility? 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