{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:53:52Z","timestamp":1790909632641,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine (1) Whether the presence and severity of recipient twin cardiomyopathy in the setting of twin\u2010to\u2010twin transfusion syndrome are associated with worse perinatal outcomes when compared to recipient twins without evidence of cardiomyopathy and (2) The optimal management strategy to reduce the likelihood of adverse perinatal outcomes when recipient twin cardiomyopathy is present.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included observational studies and randomized controlled trials of monochorionic\u2010diamniotic twin gestations affected by twin\u2010to\u2010twin transfusion syndrome, which reported the relationship between recipient twin cardiomyopathy and adverse perinatal outcomes. PubMed, CINAHAL, Scopus, Embase, and the Cochrane Central Register of Controlled Trials were queried from January 2004 to December 2025. The primary outcome was single and dual twin survival at 6\u00a0months of life. The secondary outcomes were the frequency of live birth of one or both twins; gestational age at the time of delivery; latency from diagnosis of twin\u2010to\u2010twin transfusion syndrome to delivery; birthweight of living twins; newborn length(s) of stay; need for neonatal intensive care unit admission; single and dual twin survival at 0 and 1\u00a0month of life; postnatal recipient twin cardiomyopathy (inclusive of right ventricular outflow tract obstruction); and frequency of neonatal complications at 6\u00a0months of life. Assessment of bias was performed using the Cochrane Risk\u2010of\u2010Bias and Newcastle\u2010Ottawa tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 207 abstracts available, 13 met the inclusion criteria. None of the studies reported the primary outcome defined by the systematic review, but did report on multiple secondary outcomes. Most manuscripts (10\/13) used the Myocardial Performance Index to define recipient twin cardiomyopathy. One manuscript reported on the use of calcium channel blockers in addition to selective fetoscopic photocoagulation, and its relationship with adverse perinatal outcomes. Most studies exhibited a low risk of bias. Three out of 10 manuscripts using the Myocardial Performance Index demonstrated a relationship between the presence and severity of recipient twin cardiomyopathy and adverse perinatal outcomes. Two manuscripts demonstrated that the use of calcium channel blockers perioperatively may be associated with a reduced frequency of adverse perinatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A small number of studies have assessed recipient twin cardiomyopathy's role in the risk of adverse perinatal outcomes or whether unique forms of treatment may improve the risk of perinatal outcomes. Further, studies suffer from a lack of long\u2010term neonatal follow\u2010up. Future studies should investigate whether other markers of recipient twin cardiac compromise are associated with adverse perinatal outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70141","type":"journal-article","created":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T16:43:23Z","timestamp":1775407403000},"page":"1159-1172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interventions and Perinatal Outcomes Associated With Recipient Twin Cardiomyopathy in the Setting of Twin\u2010To\u2010Twin Transfusion Syndrome: A Systematic Review"],"prefix":"10.1002","volume":"46","author":[{"given":"Briana","family":"Tolbert","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Biological Sciences Division The University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhya","family":"Chandrasekaran","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Biological Sciences Division The University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanya","family":"Manthena","sequence":"additional","affiliation":[{"name":"Biological Sciences Division Center for Interdisciplinary Inquiry and Innovation in Sexual and Reproductive Health The University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Sudilovsky","sequence":"additional","affiliation":[{"name":"Biological Sciences Division Pritzker School of Medicine The University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7246-4563","authenticated-orcid":false,"given":"Andrew","family":"Rausch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Biological Sciences Division The University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan E.","family":"Longman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Biological Sciences Division The University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Ville","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Fetal Medicine and Surgery Necker\u2010Enfants Malades Hospital APHP  Paris France"},{"name":"Department of Obstetrics, Fetal Medicine, and Surgery Paris Descartes University L'h\u00f4pital Necker\u2010Enfants malades (AP\u2010HP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6952-9955","authenticated-orcid":false,"given":"Ashish","family":"Premkumar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Biological Sciences Division The University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2024.07.017"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000313300"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp\u201020\u2010264"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.15386\/mpr\u20101481"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3959"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.08.013"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.06.070"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.Pdr.0000180558.03164.E8"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7200292"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5221"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.12.006"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100029\u20101215430"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5211"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032597"},{"key":"e_1_2_12_17_1","unstructured":"Clarivate.Endnote 20 (2019): Philadelphia PA."},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010016\u20100384\u20104"},{"key":"e_1_2_12_19_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","year":"2011"},{"key":"e_1_2_12_20_1","unstructured":"G.Wells B.Shea D.O\u2019Connell et\u00a0al. \u201cThe Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta\u2010Analyses \u201d. 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