{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:01:25Z","timestamp":1786118485808,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The impact of prenatal diagnosis timing in posterior urethral valves is unclear. We aimed to compare renal function between patients with suspected PUV diagnosed before or after 28\u00a0weeks of gestation in a population who underwent systematic T2 and T3 ultrasounds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective analysis of a prospective cohort of patients with prenatally suspected and postnatally confirmed PUV. Patients were stratified by timing of prenatal ultrasound detection of urinary tract abnormalities (T2 vs T3). We compared nadir creatinine and mid\u2010term eGFR (&gt; 5\u00a0years of follow\u2010up).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      72 boys with postnatally confirmed PUV were included. Thirty\u2010seven patients (51%) were diagnosed before 28\u00a0weeks' gestation (T2 group). This early group had significantly higher NC values (median 38 vs. 26\u00a0\u03bcmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) and lower eGFR at mid\u2010term follow\u2010up (median 85 vs. 105\u00a0mL\/min\/1.73\u00a0m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) compared to the T3 group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PUV suspected during the second trimester of gestation is associated with significantly worse NC and mid\u2010term renal function compared with those suspected later in pregnancy (T3). Reports of prenatal diagnosis of PUV should dichotomize between T2 and T3 diagnoses. The true rate of PUV that could be diagnosed prenatally is higher than expected.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70155","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T15:10:03Z","timestamp":1776784203000},"page":"1339-1344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prenatal Diagnosis of Posterior Urethral Valves: Timing of Diagnosis and Mid\u2010Term Renal Function When Second and Third Trimester Ultrasounds Are Systematically Performed"],"prefix":"10.1002","volume":"46","author":[{"given":"Silvia","family":"Pecorelli","sequence":"first","affiliation":[{"name":"Pediatric Urology CHU Pellegrin\u2010Enfants  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Glenisson","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Necker Enfant\u2010Malades  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3617-4849","authenticated-orcid":false,"given":"Matthieu","family":"Peycelon","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Hopital Robert Debre  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Suply","sequence":"additional","affiliation":[{"name":"Pediatric Surgery CHU de la Reunion  Saint\u2010Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Faraj","sequence":"additional","affiliation":[{"name":"Pediatric Surgery CHU Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc\u2010David","family":"Leclair","sequence":"additional","affiliation":[{"name":"Pediatric Surgery CHU Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5829-8167","authenticated-orcid":false,"given":"Thomas","family":"Blanc","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Necker Enfant\u2010Malades  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Kalfa","sequence":"additional","affiliation":[{"name":"Pediatric Surgery CHU Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Clermidi","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Hopital Trousseau  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4378-3570","authenticated-orcid":false,"given":"Alexis P.","family":"Arnaud","sequence":"additional","affiliation":[{"name":"Pediatric Surgery CHU Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Faure","sequence":"additional","affiliation":[{"name":"Pediatric Surgery CHU Marseille  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Ballouhey","sequence":"additional","affiliation":[{"name":"Pediatric Surgery CHU Limoges  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Boudaoud","sequence":"additional","affiliation":[{"name":"Pediatric Surgery CHU Reims  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Chaussy","sequence":"additional","affiliation":[{"name":"Pediatric Surgery CHU Besan\u00e7on  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Harper","sequence":"additional","affiliation":[{"name":"Pediatric Urology CHU Pellegrin\u2010Enfants  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Statpearls, Treasure Island (FL)","author":"Bingham G.","year":"2024"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2018.10.091"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/jarr.2001.26348"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u2010410x.1988.tb04267.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.01.023"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6413"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008030287"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2021.08.024"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15708"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2018.11.005"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.purol.2012.10.015"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2010.08.002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.06.071"},{"key":"e_1_2_9_15_1","volume-title":"Statpearls, Treasure Island (FL)","author":"Gomez Acevedo H.","year":"2025"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.01.011"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.27684"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15163"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20105347(01)64379\u20109"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8831"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.1057092"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1085143"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15844"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010017\u20103593\u20108"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010025\u201003712\u20105"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14070756"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2015.10.009"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2021.08.003"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000004612"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.70155","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.70155","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.70155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T15:55:18Z","timestamp":1786031718000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.70155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/pd.70155"],"URL":"https:\/\/doi.org\/10.1002\/pd.70155","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]},"assertion":[{"value":"2025-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}