{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:07:45Z","timestamp":1778897265954,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Characterize neuroimaging findings in foetuses with anaemia and identify associated risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study of pregnancies with foetal anaemia (defined as haemoglobin &gt;\u00a02 standard deviations below the gestational age mean) confirmed by foetal blood sampling (FBS) and treated with intrauterine transfusion (IUT) at a tertiary centre between 2011 and 2024. Prenatal and\/or early postnatal neuroimaging findings and perinatal outcomes were reviewed. Multivariable logistic regression was used to identify factors associated with brain injury on neuroimaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 100 foetuses with foetal anaemia that underwent neuroimaging, 93 met the eligibility criteria. Brain injuries were identified in 48 foetuses (52%). Injuries included intracranial haemorrhage (48%), ischaemia (21%), combined injury (6%), and non\u2010specific injuries (25%). Imaging was performed prenatally (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a036), postnatally (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a036), or both (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a021). Male sex was independently associated with brain injury (adjusted OR 5.04, 95% CI 1.64\u201315.52;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005). Anaemia severity, hydrops, cardiac dysfunction, and gestational age at diagnosis were not associated with brain injury. Immediate postnatal outcomes did not differ between the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a clinically selected cohort of foetuses with anaemia who underwent neuroimaging after IUT, brain injuries were frequent and heterogeneous. These findings support the need for prospective studies with standardized imaging and longitudinal follow\u2010up to define true risk and identify subgroups most likely to benefit from surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70168","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T01:13:31Z","timestamp":1778462011000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroimaging Findings and Risk Factors for Brain Injury in Foetuses Treated for Anaemia"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9181-3095","authenticated-orcid":false,"given":"Laurence Sophie","family":"Carmant","sequence":"first","affiliation":[{"name":"Ontario Foetal Centre Mount Sinai Hospital  Toronto Ontario Canada"},{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Robles","sequence":"additional","affiliation":[{"name":"University of Toronto  Toronto Ontario Canada"},{"name":"Department of Diagnostic &amp; Interventional Radiology The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungwoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Maternal\u2010Infant Care Research Centre Mount Sinai Hospital  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9920-0488","authenticated-orcid":false,"given":"Prakesh S.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Division of Neonatology Mount Sinai Hospital  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Ryan","sequence":"additional","affiliation":[{"name":"Ontario Foetal Centre Mount Sinai Hospital  Toronto Ontario Canada"},{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elka","family":"Miller","sequence":"additional","affiliation":[{"name":"University of Toronto  Toronto Ontario Canada"},{"name":"Department of Diagnostic &amp; Interventional Radiology The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6352-4846","authenticated-orcid":false,"given":"Shiri","family":"Shinar","sequence":"additional","affiliation":[{"name":"Ontario Foetal Centre Mount Sinai Hospital  Toronto Ontario Canada"},{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200001063420102"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17555"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7696"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.07.014"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100412.2011.01353.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328683"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029\u20107844(96)00113\u20105"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.12.012"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.09.024"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.12.035"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild\u20102024\u2010328135"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4152"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20846"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2011.07.003"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.1001973"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489881"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234\u2010024\u201003373\u20104"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4577"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2018.05.044"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23616"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.01.059"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17956"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469\u20100705.1991.01050309.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109378(90)90990\u2010o"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.13654"},{"issue":"1","key":"e_1_2_10_27_1","first-page":"e15","article-title":"Fetal and Neonatal Alloimmune Thrombocytopenia","volume":"6","author":"Espinoza J. 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