{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:00:38Z","timestamp":1786118438344,"version":"build-2736575974"},"reference-count":134,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Southeast Asian (SEA) countries face persistent challenges in equitable healthcare delivery. Given the high prevalence of aneuploidy, increasing use of advanced prenatal screening technologies, and challenges reported in other regions, this study aimed to identify and assess existing policies and guidelines as well as the enablers and barriers to implementing prenatal aneuploidy screening in SEA. Using the PRISMA framework, we searched seven databases, conducted web searches, reviewed reference lists, and gathered input from key informants. Narrative synthesis was used to interpret and summarise data. We included 83 published documents and verbal insights from four key informants, identifying 17 topics on enablers and barriers grouped into four domains: (1) policies and guidelines, (2) healthcare infrastructure, (3) access to screening, and (4) culture and attitudes of healthcare providers and parents. Effective implementation requires surveillance of aneuploidy and screening practices to understand their impact on public health and national economies. Policy development should consider test performance, healthcare capacity, infrastructure readiness, budget, stakeholder perceptions, cultural norms, and legal frameworks, and be translated into clear guidelines. Sustainable implementation depends on continuous monitoring, ongoing education, collaboration, and regular policy updates.<\/jats:p>","DOI":"10.1002\/pd.70171","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T10:39:51Z","timestamp":1779532791000},"page":"1393-1410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prenatal Screening for Common Aneuploidy in Southeast Asian Countries: A Systematic Review of Challenges and Opportunities"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1588-8789","authenticated-orcid":false,"given":"Rapphon","family":"Sawaddisan","sequence":"first","affiliation":[{"name":"Faculty of Health Graduate School of Health Genetic Counselling University of Technology Sydney  Sydney Australia"},{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Prince of Songkla University  Hat Yai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucinda","family":"Freeman","sequence":"additional","affiliation":[{"name":"Faculty of Health Graduate School of Health Genetic Counselling University of Technology Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Turbitt","sequence":"additional","affiliation":[{"name":"Faculty of Health Graduate School of Health Genetic Counselling University of Technology Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"McEwen","sequence":"additional","affiliation":[{"name":"Faculty of Health Graduate School of Health Genetic Counselling University of Technology Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Worldometer. \u201cPopulation of South\u2010Eastern Asia 2024\u201d. Accessed October 31 2024 https:\/\/www.worldometers.info\/world\u2010population\/south\u2010eastern\u2010asia\u2010population\/."},{"key":"e_1_2_12_3_1","volume-title":"Understanding Country Income: World Bank Group Income Classifications for FY26 (July 1, 2025\u2013June, 2026)","author":"Metreau E."},{"key":"e_1_2_12_4_1","unstructured":"World Health Organization. \u201cMaternal Mortality Ratio (Per 100 000 Live Births) \u201d Accessed November 7 2024 https:\/\/www.who.int\/data."},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(10)61507\u20103"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2018.09.028"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12939\u2010023\u201001974\u20108"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31701"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004084"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61365"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1706537"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18020419"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12687\u2010020\u201000458\u20104"},{"key":"e_1_2_12_14_1","first-page":"332","volume-title":"Williams Obstetrics","author":"Cunningham F.","year":"2022"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010023\u201001330\u2010y"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.908482"},{"key":"e_1_2_12_17_1","unstructured":"Health Intervention and Technology Assessment Program. \u201cResearch Project: Assessing the Pilot Study for the Prevention of down syndrome\u201d. Accessed May 13 2024 https:\/\/www.hitap.net\/wp\u2010content\/uploads\/2018\/01\/Report_final_Down\u2010Syndrome\u20102.pdf."},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1481032"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6239"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12687\u2010022\u201000597\u2010w"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13152570"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4637"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010genom\u2010083118\u2010015053"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6043"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010021\u201000970\u20102"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0298643"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.136507"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7647"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2321031974"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.NAJ.0000451683.66447.89"},{"key":"e_1_2_12_32_1","volume-title":"Standard Quality Assessment Criteria for Evaluating Primary Research Papers from a Variety of Fields","author":"Kmet L. M.","year":"2004"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.090449"},{"key":"e_1_2_12_34_1","volume-title":"Guidance on the Conduct of Narrative Synthesis in Systematic Reviews: A Product from the ESRC Methods Programme (Version I)","author":"Popay J.","year":"2006"},{"key":"e_1_2_12_35_1","volume-title":"Birth Defects in South\u2010East Asia: A Public Health Challenge\u2014Situation Analysis","author":"World Health Organization, Regional Office for South\u2010East Asia","year":"2013"},{"key":"e_1_2_12_36_1","unstructured":"College of Obstetricians and Gynaecologists S F. M.Lai G. S.Yeo et\u00a0al. \u201cRecommended \u2018Best Practice\u2019 Guidelines on Antenatal Screening for Trisomy 21 (Down Syndrome) and Other Fetal Aneuploidies \u201d (2008) https:\/\/www.ams.edu.sg\/view\u2010pdf.aspx?file=media%5C754_fi_329.pdf&ofile=Consensus_Statement_Downs_Syndrome.pdf."},{"key":"e_1_2_12_37_1","first-page":"1","volume-title":"\u0e04\u0e39\u0e48\u0e21\u0e37\u0e2d\u0e1d\u0e36\u0e01\u0e2d\u0e1a\u0e23\u0e21 \u0e2b\u0e25\u0e31\u0e01\u0e2a\u0e39\u0e15\u0e23 \u0e01\u0e32\u0e23\u0e43\u0e2b\u0e49\u0e01\u0e32\u0e23\u0e1b\u0e23\u0e36\u0e01\u0e29\u0e32\u0e17\u0e32\u0e07\u0e1e\u0e31\u0e19\u0e18\u0e38 \u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c \u0e01\u0e25\u0e38\u0e48\u0e21\u0e2d\u0e32 \u0e01\u0e32\u0e23\u0e14\u0e32\u0e27\u0e19\u0e4c [Training Manual:\u00a0Genetic Counselling Course for down Syndrome]","author":"Department of Health, Ministry of Public Health","year":"2020"},{"key":"e_1_2_12_38_1","unstructured":"Royal Thai College of Obstetricians and Gynaecologists. \u201cRTCOG Clinical Practice Guideline: Standard Obstetric Ultrasound Examination \u201d (2023):1\u201316 https:\/\/www.rtcog.or.th\/files\/1685345629_4723295a476aa866d255.pdf."},{"key":"e_1_2_12_39_1","unstructured":"Office of Health Promotion Department of Health Ministry of\u00a0Public Health.\u0e41\u0e19\u0e27\u0e1b\u0e0f\u0e34\u0e1a\u0e31\u0e15\u0e34\u0e01\u0e32\u0e23\u0e43\u0e2b\u0e49\u0e1a\u0e23\u0e34\u0e01\u0e32\u0e23\u0e15\u0e23\u0e27\u0e08\u0e04\u0e31\u0e14\u0e01\u0e23\u0e2d\u0e07 \u0e43\u0e19\u0e2b\u0e0d\u0e34\u0e07\u0e15\u0e31\u0e49\u0e07\u0e04\u0e23\u0e23\u0e20\u0e4c\u0e14\u0e49\u0e27\u0e22 \u0e27\u0e34\u0e18\u0e35 Quadruple test \u0e2a\u0e33\u0e2b\u0e23\u0e31\u0e1a\u0e1c\u0e39\u0e49\u0e1b\u0e0f\u0e34\u0e1a\u0e31\u0e15\u0e34\u0e07\u0e32\u0e19 [Guidelines for providing screening services in pregnant women using the Quadruple test method for practitioners] (2021) 1\u201324."},{"key":"e_1_2_12_40_1","unstructured":"Maternal and Child Health Group Bureau of Health Promotion Department of Health Ministry of Public Health. \u201cManual for the Implementation of the down syndrome Prevention and Control Program in Thailand \u201d (2015) http:\/\/203.157.71.148\/data\/cluster\/mom\/download\/ManualDW.pdf."},{"key":"e_1_2_12_41_1","unstructured":"Royal Thai College of Obstetricians and Gynaecologists. \u201cRTCOG Clinical Practice Guideline: Down Syndrome Screening \u201d (2025):1\u201313 https:\/\/www.rtcog.or.th\/files\/1754468814_90e97c221a1f790565eb.pdf."},{"key":"e_1_2_12_42_1","unstructured":"Vietnam Ministry of Health.QUY\u1ebeT \u0110\u1ecaNH V\u1ec1 vi\u1ec7c ban h\u00e0nh H\u01b0\u1edbng d\u1eabn v\u1ec1 chuy\u00ean m\u00f4n k\u1ef9 thu\u1eadt trong s\u00e0ng l\u1ecdc ch\u1ea9n \u0111o\u00e1n \u0111i\u1ec1u tr\u1ecb tr\u01b0\u1edbc sinh v\u00e0 s\u01a1 sinh [Decision on promulgating the technical guidelines on prenatal and neonatal screening diagnosis and treatment] (2020)."},{"key":"e_1_2_12_43_1","volume-title":"Ministry of Health Malaysia; Jawatankuasa Pengurusan Dan Perkembangan O&G KKM (JPPOBG). Handbook of Obstetrics Guideline","author":"Obstetrical & Gynaecological and Paediatric Services Unit of the Medical Development Division","year":"2024"},{"key":"e_1_2_12_44_1","unstructured":"Ministry of Health Malaysia.Perinatal Care Manual 4th ed. (2023) 1\u2013460 https:\/\/hq.moh.gov.my\/bpkk\/images\/PERINATAL_CARE_MANUAL_4th_Edition_2020_11Mei2023.pdf."},{"key":"e_1_2_12_45_1","first-page":"1","volume-title":"\u0e04\u0e39\u0e48\u0e21\u0e37\u0e2d \u0e01\u0e32\u0e23\u0e1d\u0e32\u0e01\u0e04\u0e23\u0e23\u0e20\u0e4c \u0e2a\u0e33\u0e2b\u0e23\u0e31\u0e1a \u0e1a\u0e38\u0e04\u0e25\u0e32\u0e01\u0e23 \u0e2a\u0e32\u0e18\u0e32\u0e23\u0e13\u0e2a\u0e38\u0e02 [Pregnancy Care Guide for Public Health Personnel]","author":"Department of Health, Thailand Ministry of Public Health","year":"2022"},{"key":"e_1_2_12_46_1","first-page":"1","volume-title":"RTCOG Clinical Practice Guideline: Prenatal Care","author":"Royal Thai College of Obstetricians and Gynaecologists","year":"2023"},{"key":"e_1_2_12_47_1","unstructured":"Philippine Obstetrical and Gynecological Society (Foundation) Inc. \u201cPhilippine Society of Maternal Fetal Medicine Inc. COVID\u201019 and Pregnancy: A Guide to MFM Specialists and General Obstetric Practitioners \u201d (2021):1\u20138 https:\/\/psmfm.org\/wp\u2010content\/uploads\/2021\/02\/Covid_1.pdf."},{"key":"e_1_2_12_48_1","volume-title":"Marriage and Parenthood Schemes","author":"Ministry of Health Singapore"},{"key":"e_1_2_12_49_1","unstructured":"The Thai National Health Security Office. \u201cAnnouncement From the National Health Security Office Regarding the Reimbursement for Public Health Services \u201d (2025):1\u20135 http:\/\/secretary.dms.go.th\/book\/data\/289.pdf."},{"key":"e_1_2_12_50_1","volume-title":"Updated Code of Practice on the Standard for the Provision of Clinical Genetic\/Genomic Testing Services and Clinical Laboratory Genetic\/Genomic Testing Services","author":"Ministry of Health Singapore","year":"2020"},{"issue":"2","key":"e_1_2_12_51_1","first-page":"41","article-title":"Evaluating the Deciding Factors for Termination of Pregnancy With Fetal Anomaly: Experience From Two Centers in Malaysia","volume":"4","author":"Nazimah I.","year":"2010","journal-title":"International Journal of Science and Mathematics Education"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.37268\/mjphm\/vol.18\/no.1\/art.246"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010020\u201003279\u2010y"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.47102\/annals\u2010acadmedsg.v44n2p43"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2016114"},{"issue":"2","key":"e_1_2_12_56_1","first-page":"152","article-title":"False Positive Rate of Serum Markers for down syndrome Screening: Does Transportation Have Any Effect?","volume":"95","author":"Sirichotiyakul S.","year":"2012","journal-title":"Journal of the Medical Association of Thailand"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0291622"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913\u2010019\u20104699\u20104"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010023\u201006170\u20108"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/nhs.12190"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1463367"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/ijph.2023.1605441"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1358264"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913\u2010019\u20104446\u2010x"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0251381"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1362383"},{"issue":"4","key":"e_1_2_12_67_1","first-page":"269","article-title":"Accuracy of the Combined First Trimester Down Syndrome Screening Test and the Optimum Range of the Cut\u2010Off Point for Intermediate\u2010Risk Identification: Twelve Years\u2019 Experience","volume":"32","author":"Pinnington T. R.","year":"2024","journal-title":"Thai Journal of Obstetrics and Gynaecology"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.70305"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182538"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2011.11.026"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447\u20100756.2011.01769.x"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6322"},{"issue":"1","key":"e_1_2_12_73_1","first-page":"26","article-title":"Knowledge, Attitude and Practices of Obstetricians and Gynecologists on Non\u2010Invasive Prenatal Testing With Cell Free Fetal DNA in a Private Tertiary Hospital","volume":"44","author":"Panes K. D. P.","year":"2020","journal-title":"Philippine Journal of Obstetrics and Gynecology"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00038\u2010016\u20100897\u20106"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.5812\/jnms\u2010147406"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4602"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338656"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2015009"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2021.05.021"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.31083\/J.CEOG4804136"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm\u20102014\u20100201"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010021\u201004332\u20100"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0284829"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12290"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.14456\/gag.2020.1"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4775"},{"issue":"2","key":"e_1_2_12_87_1","first-page":"32","article-title":"A Paired\u2010end Sequencing Based Noninvasive Prenatal Testing (NIPT) to Screen Trisomy 21 and Trisomy 18 in Twin Pregnancies","volume":"2","author":"Tangmansakulchai K.","year":"2021","journal-title":"Health Science Journal of Thailand"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.1256"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.4172\/2469\u20109853.1000137"},{"issue":"10","key":"e_1_2_12_90_1","first-page":"S89","article-title":"Second Trimester Genetic Ultrasound for Down Syndrome Screening at Srinagarind Hospital","volume":"97","author":"Ratanasiri T.","year":"2014","journal-title":"Journal of the Medical Association of Thailand"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010025\u201008303\u20107"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S526271"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447\u20100756.2010.01521.x"},{"issue":"11","key":"e_1_2_12_94_1","article-title":"Value of Non\u2010Invasive Prenatal Test (NIPT) for Comprehensive Fetal Aneuploidies Screening","volume":"184","author":"Phan H. C.","year":"2024","journal-title":"Journal of Media Research"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.38103\/jcmhch.83.2"},{"issue":"4","key":"e_1_2_12_96_1","first-page":"667","article-title":"Cost\u2010Benefit Analysis of Prenatal Screening and Diagnosis for Down Syndrome in Thailand","volume":"21","author":"Pattanaphesaj J.","year":"2012","journal-title":"Journal of Health Science of Thailand"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.4172\/2375\u20104273.1000207"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971\u20106866.142880"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1080\/20479700.2020.1758893"},{"key":"e_1_2_12_100_1","volume-title":"The barriers and facilitators to the utilization of prenatal genetic tests and prenatal genetic counseling in a Philippine private tertiary hospital [master\u2019s thesis]","author":"Talapian G. L. M.","year":"2021"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.284"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224006"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31703"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12687\u2010021\u201000543\u20102"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010013\u20109587\u20101"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.247"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes15060780"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1804"},{"issue":"4","key":"e_1_2_12_109_1","first-page":"12","article-title":"Establishment of the Philippine Birth Defects Surveillance","volume":"45","author":"Padilla C. D.","year":"2011","journal-title":"Acta Medica Philippina"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010015\u20109823\u2010y"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12687\u2010014\u20100193\u20101"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010013\u20109646\u20107"},{"issue":"1","key":"e_1_2_12_113_1","first-page":"7","article-title":"The Knowledge and Attitudes of Thai Obstetrics and Gynaecology Residents Towards Down Syndrome Screening","volume":"96","author":"Kor\u2010Anantakul O.","year":"2013","journal-title":"Journal of the Medical Association of Thailand"},{"key":"e_1_2_12_114_1","volume-title":"Revised Penal Code of the Philippines (Act No. 3815), Book II: Crimes and Penalties (Arts 256\u2013259)","author":"Government of the Philippines"},{"key":"e_1_2_12_115_1","volume-title":"Penal Code (Chapter 22) (Revised Edition)","author":"Government of Brunei Darussalam"},{"key":"e_1_2_12_116_1","volume-title":"Penal Code (Incorporating Amendments to 25 March 2019)","author":"Government of Myanmar"},{"key":"e_1_2_12_117_1","volume-title":"Law No. 1 of 2023 on the Criminal Code (Kitab Undang\u2010Undang Hukum Pidana)","author":"Government of Indonesia"},{"key":"e_1_2_12_118_1","volume-title":"\u0e82\u0ecd\u0ec9\u0e95\u0ebb\u0e81\u0ea5\u0ebb\u0e87 \u0ec0\u0ea5\u0e81\u0e97\u0eb5 2077\/\u0e81\u0eb0\u0e8a\u0ea7\u0e87\u0eaa\u0eb2\u0e97\u0eb2\u0ea5\u0eb0\u0e99\u0eb0\u0eaa\u0eb8\u0e81 \u0ea7\u0ec8\u0eb2\u0e94\u0ec9\u0ea7\u0e8d \u0e81\u0eb2\u0e99\u0e84\u0eb8\u0ec9\u0ea1\u0e84\u0ead\u0e87 \u0e81\u0eb2\u0e99\u0ec3\u0eab\u0ec9\u0e96\u0eb7\u0e9e\u0eb2\u0ec1\u0e97\u0e99 \u0ec1\u0ea5\u0eb0 \u0e81\u0eb2\u0e99\u0ec3\u0eab\u0ec9\u0eab\u0ebc\u0eb8\u0ea5\u0eb9\u0e81 (Decision No. 2077\/MOH on the Management of Gestational Surrogacy and Induced Abortion; July 8, 2021) [in Lao]","author":"Ministry of Health (Lao People\u2019s Democratic Republic)"},{"key":"e_1_2_12_119_1","volume-title":"Penal Code (Act 574)","author":"Government of Malaysia"},{"key":"e_1_2_12_120_1","volume-title":"Penal Code (Decree\u2010Law No. 19\/2009). Ministry of Justice","author":"Government of Timor\u2010Leste"},{"key":"e_1_2_12_121_1","volume-title":"Law on Abortion","author":"Ministry of Health (Cambodia)"},{"key":"e_1_2_12_122_1","volume-title":"Termination of Pregnancy Act 1974 (2020 Revised Edition)","author":"Government of Singapore"},{"key":"e_1_2_12_123_1","volume-title":"\u0e1e\u0e23\u0e30\u0e23\u0e32\u0e0a\u0e1a\u0e31\u0e0d\u0e0d\u0e31\u0e15\u0e34\u0e41\u0e01\u0e49\u0e44\u0e02\u0e40\u0e1e\u0e34\u0e48\u0e21\u0e40\u0e15\u0e34\u0e21\u0e1b\u0e23\u0e30\u0e21\u0e27\u0e25\u0e01\u0e0e\u0e2b\u0e21\u0e32\u0e22\u0e2d\u0e32\u0e0d\u0e32 (\u0e09\u0e1a\u0e31\u0e1a\u0e17\u0e35\u0e48 28) \u0e1e.\u0e28. 2564 [Act Amending the Penal Code (No. 28), B.E. 2564 (2021)] [in Thai]","author":"Government of Thailand"},{"key":"e_1_2_12_124_1","unstructured":"National Assembly of Viet Nam.Lu\u1eadt B\u1ea3o V\u1ec7 S\u1ee9c Kh\u1ecfe Nh\u00e2n D\u00e2n S\u1ed1 21 LCT\/H\u0110NN8 Ng\u00e0y 30 Th\u00e1ng 6 N\u0103m 1989 [Law on Protection of the People\u2019s Health No. 21\u2010LCT\/H\u0110NN8 June 30 1989] [in Vietnamese]. National Assembly of Viet Nam Website. Law Enacted 1989. Accessed April 3 2026."},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1004551"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13690\u2010023\u201001159\u20103"},{"key":"e_1_2_12_127_1","unstructured":"World Health Organization World Bank Group. \u201cTracking Universal Health Coverage: 2023 Global Monitoring Report\u201d. Accessed September 20 2025 https:\/\/iris.who.int\/bitstream\/handle\/10665\/374059\/9789240080379\u2010eng.pdf?sequence=1."},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17103366"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5182"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S67124"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010012\u20109545\u20103"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1518"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.13522"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2016.39"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2024.102543"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.70171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.70171","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.70171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T15:54:52Z","timestamp":1786031692000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.70171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,23]]},"references-count":134,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/pd.70171"],"URL":"https:\/\/doi.org\/10.1002\/pd.70171","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,23]]},"assertion":[{"value":"2026-01-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}