{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:56:12Z","timestamp":1791381372139,"version":"4.3.3"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate whether fetal pulmonary artery (PA) measurements and PA Doppler parameters such as acceleration time\/ejection time (AT\/ET) ratio predict respiratory outcomes in surviving neonates with left\u2010sided congenital diaphragmatic hernia (CDH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective single\u2010center study included fetuses with left\u2010sided CDH born between 2016 and 2024. Fetal echocardiography assessed PA Doppler parameters, including the AT\/ET ratio, peak early diastolic reverse flow, and pulsatility index. Neonatal morbidity using the use of inhaled nitric oxide (iNO) was analyzed in relation to prenatal ultrasound parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      27 fetuses with left\u2010sided CDH were analyzed, and 3 neonates died. Among 23 survivors without structural abnormalities, the fetal contralateral PA AT\/ET ratio was significantly lower in the iNO group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.019) and negatively correlated with iNO duration (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.57). ROC analysis showed that an AT\/ET cut\u2010off of 0.17 predicted iNO use with 63% sensitivity and 100% specificity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study, the AT\/ET ratio correlated with postnatal iNO use in fetuses with left\u2010sided CDH. It can be measured non\u2010invasively, and may be useful for risk stratification and prenatal parental counseling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70176","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T12:45:48Z","timestamp":1778762748000},"page":"1079-1085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Fetal Pulmonary Artery Acceleration Time\/Ejection Time Ratio and Postnatal Inhaled Nitric Oxide Requirement in Surviving Infants With Left\u2010Sided Congenital Diaphragmatic Hernia"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4075-0481","authenticated-orcid":false,"given":"Kyoko","family":"Namimatsu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University  Bunkyo\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8991-4551","authenticated-orcid":false,"given":"Yuka","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University  Bunkyo\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Seyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University  Bunkyo\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2389-8996","authenticated-orcid":false,"given":"Shun","family":"Masaoka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University  Bunkyo\u2010ku 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