{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:53:54Z","timestamp":1790909634046,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007380","name":"Fondation de l'Avenir pour la Recherche M\u00e9dicale Appliqu\u00e9e","doi-asserted-by":"publisher","award":["AP\u2010RM\u201023\u2010019"],"award-info":[{"award-number":["AP\u2010RM\u201023\u2010019"]}],"id":[{"id":"10.13039\/100007380","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006005","name":"Agence de la Biom\u00e9decine","doi-asserted-by":"publisher","award":["23AMP002"],"award-info":[{"award-number":["23AMP002"]}],"id":[{"id":"10.13039\/501100006005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019125","name":"Sorbonne Universit\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate uterine healing at delivery after fetoscopic myelomeningocele (MMC) closure in an ovine model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This descriptive study was conducted in Romane ewes. Fetal MMC lesions were created after hysterotomy at 75\u00a0days of gestation. Fetoscopic MMC closure using three trocars was performed at 90\u00a0days of gestation and cesarean delivery at 143\u00a0days. Subtotal hysterectomy was performed, and each hysterectomy specimen was examined in fresh condition. The areas of interest and the surrounding intact tissue were then sampled\n                      <jats:italic>en bloc<\/jats:italic>\n                      and fixed in 4% buffered formaldehyde solution for 3\u20136\u00a0weeks. Macroscopic appearance of the scars was assessed in fresh condition. Microscopic examinations were conducted in fixed samples.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The uteri of six ewes were studied. Macroscopic examination revealed identifiable fetoscopic scars without any scar dehiscence. There was no evidence of a difference in thickness between scarred and healthy adjacent myometrium, although a slightly lower proportion of muscle fibers was observed in scarred areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study demonstrates that myometrial healing of trocar orifices is complete 53\u00a0days after fetoscopic MMC closure in an ovine model. Given the limitations of an ovine model, further studies are needed to determine the risk of uterine rupture and the optimal obstetric management of patients after fetoscopic MMC closure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70177","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:10:44Z","timestamp":1778901044000},"page":"1258-1266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Fetoscopic Surgery on the Myometrium: Experimental Study in an Ovine Model of Myelomeningocele"],"prefix":"10.1002","volume":"46","author":[{"given":"Enora","family":"Parc","sequence":"first","affiliation":[{"name":"Department of Fetal Medicine Sorbonne University AP\u2010HP Armand Trousseau Hospital DMU ORIGYNE National Reference Center for Rare Diseases: Spin@  Paris France"},{"name":"Stem Cell Biotechnologies Unit INSERM 1342, CIC\u2010BT, Saint\u2010Louis Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eug\u00e9nie","family":"Jolivet","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine Sorbonne University AP\u2010HP Armand Trousseau Hospital DMU ORIGYNE National Reference Center for Rare Diseases: Spin@  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corentin","family":"Maillet","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine Sorbonne University AP\u2010HP Armand Trousseau Hospital DMU ORIGYNE National Reference Center for Rare Diseases: Spin@  Paris France"},{"name":"Stem Cell Biotechnologies Unit INSERM 1342, CIC\u2010BT, Saint\u2010Louis Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2665-8292","authenticated-orcid":false,"given":"Yoann","family":"Athiel","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine Sorbonne University AP\u2010HP Armand Trousseau Hospital DMU ORIGYNE National Reference Center for Rare Diseases: Spin@  Paris France"},{"name":"Stem Cell Biotechnologies Unit INSERM 1342, CIC\u2010BT, Saint\u2010Louis Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Marie","family":"Jouannic","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine Sorbonne University AP\u2010HP Armand Trousseau Hospital DMU ORIGYNE National Reference Center for Rare Diseases: Spin@  Paris France"},{"name":"Working Group Spina Bifida and Other Dysraphisms European Reference Network ITHACA  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Guilbaud","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine Sorbonne University AP\u2010HP Armand Trousseau Hospital DMU ORIGYNE National Reference Center for Rare Diseases: Spin@  Paris France"},{"name":"Stem Cell Biotechnologies Unit INSERM 1342, CIC\u2010BT, Saint\u2010Louis Hospital  Paris France"},{"name":"Working Group Spina Bifida and Other Dysraphisms European Reference Network ITHACA  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1014379"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2021.102155"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471\u20100528.15312"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.03.008"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.05.054"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.09.065"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19104"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13430"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20308"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000001941"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.05.044"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19104"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000002577"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2027030"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa032597"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2016.10.004"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.091209"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gofs.2022.07.005"},{"key":"e_1_2_11_20_1","volume-title":"Blaustein's Pathology of the Female Genital Tract","author":"Kurman R. 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