{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:53:52Z","timestamp":1790909632782,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030853","name":"Department of Biomedical Engineering, Case Western Reserve University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030853","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008102","name":"University of Cincinnati","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare postnatal MRI outcomes after prenatal myelomeningocele repair using three different dural substitutes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      32 sheep fetuses were included, with 34.3%(11\/32) serving as healthy controls and the remaining undergoing prenatal spinal lumbar defect creation to recreate a myelomeningocele in the fetus. 90.5% (19\/21) of sheep fetuses with surgically created MMC underwent repair using traditional collagen (Durapair) patch (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a06), HUC matrix (NEOX RT) patch (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a06), or a novel PLA\/PCL patch (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a07). All sheep underwent brain and spine MRI within 24\u00a0h after delivery. Images were reviewed in Research PACS by a pediatric neuroradiologist and were assessed for ventricle size, degree of hindbrain herniation, spinal cord integrity, and fluid collection at the repair site.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was a significant reduction in hindbrain herniation in all three intervention groups when compared with MMC without prenatal intervention. There was increased incidence of complete spinal cord defect (3\/7), pseudomeningocele (5\/7) and intraspinal cyst (2\/7) at the repair site of the PLA\/PCL patch compared with the Durapair and NEOX RT patches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates equal efficacy in reducing hindbrain herniation in MMC repair by Durapair, NEOX RT, and PLA\/PCL patches by MRI. Future studies analyzing the interaction of the patches with the host tissue in animal models and clinical trials will help to better determine the true safety and efficacy of these novel patches for clinical use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70178","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:10:45Z","timestamp":1778901045000},"page":"1267-1277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MRI in Sheep Model for Myelomeningocele Repair Using a Novel Polymer and Other Dural Patches"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8251-7481","authenticated-orcid":false,"given":"Usha D.","family":"Nagaraj","sequence":"first","affiliation":[{"name":"Department of Radiology and Medical Imaging at Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Oria","sequence":"additional","affiliation":[{"name":"University of Cincinnati  Cincinnati Ohio USA"},{"name":"Center for Fetal and Placental Research Cincinnati Children's Hospital Medical Center (CCHMC)  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soner","family":"Duru","sequence":"additional","affiliation":[{"name":"Center for Fetal and Placental Research Cincinnati Children's Hospital Medical Center (CCHMC)  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Ying","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Informatics Convergent Bioscience and Technology Institute Indiana University  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth M.","family":"Kline\u2010Fath","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging at Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L.","family":"Peiro","sequence":"additional","affiliation":[{"name":"University of Cincinnati  Cincinnati Ohio USA"},{"name":"Center for Fetal and Placental Research Cincinnati Children's Hospital Medical Center (CCHMC)  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"100502","volume-title":"Interdisciplinary Neurosurgery","author":"Ntimbani 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