{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:53:31Z","timestamp":1790909611516,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the prenatal diagnosis, evolution, and perinatal management of kaposiform hemangioendothelioma (KHE) complicated by the Kasabach\u2013Merritt phenomenon (KMP), and to report the first documented use of maternal sirolimus therapy (MST) in this setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed four fetuses with a prenatal soft\u2010tissue mass suspected for KHE. Imaging characteristics, fetal complications, perinatal outcomes, and postnatal hematologic data were analyzed. MST was initiated in one severe case with rapidly progressive disease and early fetal compromise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All lesions demonstrated infiltrative margins, marked hypervascularity, and T2\u2010hyperintense signal on MRI. Three fetuses showed prenatal signs suggestive of evolving KMP. Two pregnancies were terminated. Among the two liveborn infants, one developed early neonatal KMP requiring urgent sirolimus therapy. All lesions demonstrated infiltrative margins, marked hypervascularity, and T2\u2010hyperintense signal on MRI. Three fetuses showed prenatal signs suggestive of evolving KMP. Two pregnancies were terminated. Among the two liveborn infants, one developed early neonatal KMP requiring urgent sirolimus therapy. In the most recent case, a temporal association was observed between MST initiation and early reduction of tumor infiltration on follow\u2010up MRI. The infant was delivered at 39\u00a0weeks and responded to combined sirolimus\u2013steroid therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prenatal imaging can strongly suggest KHE and identify early signs of KMP. This series provides preliminary evidence that MST may represent a promising antenatal therapeutic option in selected severe cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70180","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T19:54:57Z","timestamp":1778961297000},"page":"1278-1285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prenatal Diagnosis and Management of Kaposiform Hemangioendothelioma With Kasabach\u2013Merritt Phenomenon: Imaging Features and First Experience With Maternal Sirolimus Therapy"],"prefix":"10.1002","volume":"46","author":[{"given":"Antoine","family":"Fraissenon","sequence":"first","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Anomalies Vasculaires Superficielles Imagerie p\u00e9diatrique et f\u0153tale H\u00f4pital Femme M\u00e8re Enfant Universit\u00e9 Claude Bernard Lyon 1  Villeurbanne France"},{"name":"INSERM U1151 \u00ab M\u00e9canismes et strat\u00e9gies th\u00e9rapeutiques dans les syndromes de surcroissance et les anomalies vasculaires \u00bb Institut Necker Enfants Malades  Paris France"},{"name":"Service de Radiologie M\u00e8re\u2010Enfant H\u00f4pital Nord CHU Saint Etienne  Saint\u2010Priest\u2010en\u2010Jarez France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1999-5904","authenticated-orcid":false,"given":"Chris","family":"Minella","sequence":"additional","affiliation":[{"name":"Centre de Diagnostic Pr\u00e9natal H\u00f4pitaux de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1697-3777","authenticated-orcid":false,"given":"Marion","family":"Bordas\u2010Fournel","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Anomalies Vasculaires Superficielles Imagerie p\u00e9diatrique et f\u0153tale H\u00f4pital Femme M\u00e8re Enfant Universit\u00e9 Claude Bernard Lyon 1  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Ga\u00eblle","family":"Grebille","sequence":"additional","affiliation":[{"name":"Centre de Diagnostic Pr\u00e9natal H\u00f4pital de Saint Brieux  Saint\u2010Brieuc France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Boccara","sequence":"additional","affiliation":[{"name":"Dermatologie P\u00e9diatrique H\u00f4pital Necker  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Cassart","sequence":"additional","affiliation":[{"name":"Department of Radiology and Fetal Medicine Iris Hospitals South  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4771-8477","authenticated-orcid":false,"given":"Sarah","family":"Simon\u2010Locatelli","sequence":"additional","affiliation":[{"name":"R\u00e9animation n\u00e9onatale H\u00f4pitaux de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwenaelle","family":"Andr\u00e9","sequence":"additional","affiliation":[{"name":"Centre de Diagnostic Pr\u00e9natal CHU de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Canaud","sequence":"additional","affiliation":[{"name":"INSERM U1151 \u00ab M\u00e9canismes et strat\u00e9gies th\u00e9rapeutiques dans les syndromes de surcroissance et les anomalies vasculaires \u00bb Institut Necker Enfants Malades  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Guilhem","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Anomalies Vasculaires Superficielles Imagerie p\u00e9diatrique et f\u0153tale H\u00f4pital Femme M\u00e8re Enfant Universit\u00e9 Claude Bernard Lyon 1  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Cabet","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Anomalies Vasculaires Superficielles Imagerie p\u00e9diatrique et f\u0153tale H\u00f4pital Femme M\u00e8re Enfant Universit\u00e9 Claude Bernard Lyon 1  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Guibaud","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Anomalies Vasculaires Superficielles Imagerie p\u00e9diatrique et f\u0153tale H\u00f4pital Femme M\u00e8re Enfant Universit\u00e9 Claude Bernard Lyon 1  Villeurbanne France"},{"name":"INSERM U1151 \u00ab M\u00e9canismes et strat\u00e9gies th\u00e9rapeutiques dans les syndromes de surcroissance et les anomalies vasculaires \u00bb Institut Necker Enfants Malades  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10396\u2010025\u201001531\u20106"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.03.080"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43055\u2010023\u201001028\u20107"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/children12111429"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.580"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015\u20103257"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.3459"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44161\u2010023\u201000280\u20104"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.29191"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272\u2010025\u201000708\u20103"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.XXXX"},{"key":"e_1_2_10_13_1","unstructured":"L.Guibaud M.Bordas\u2010Fournel A.Atallah et\u00a0al. \u201cMaternal Sirolimus Therapy for Fetal Extensive Lymphatic Cystic Malformation: Selection Criteria Sirolimus Management Imaging and Clinical Outcome in a Series of 6 Cases \u201d Prenatal Diagnosis: Submitted."},{"key":"e_1_2_10_14_1","first-page":"187","article-title":"Kaposiform Hemangioendothelioma: Clinical Features, Pathology, and Treatment","volume":"15","year":"2020","journal-title":"POrphanet Journal of Rare Diseases"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.70180","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.70180","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.70180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:18:14Z","timestamp":1790907494000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.70180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,16]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/pd.70180"],"URL":"https:\/\/doi.org\/10.1002\/pd.70180","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,16]]},"assertion":[{"value":"2026-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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