{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T11:05:42Z","timestamp":1779534342870,"version":"3.53.1"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aim to expand the prenatal phenotypic spectrum of hereditary spherocytosis (HS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We reviewed four pregnancies at risk for or suspected of having HS. Prenatal ultrasound, middle cerebral artery (MCA) Doppler surveillance, genetic testing, and neonatal outcomes were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Case 1 involved a fetus with a homozygous variant in\n                      <jats:italic>SPTA1<\/jats:italic>\n                      with severe fetal anemia and nonimmune hydrops fetalis resulting in fetal demise. Case 2 involved a mother with a heterozygous\n                      <jats:italic>ANK1<\/jats:italic>\n                      variant. Fetal anemia and polyhydramnios prompted close prenatal surveillance, and the infant required four red cell transfusions. The mother of Case 3 had a heterozygous\n                      <jats:italic>SPTB<\/jats:italic>\n                      variant. Although fetal surveillance was reassuring, the neonate required quintuple phototherapy. Case 4 involved a mother with a heterozygous\n                      <jats:italic>SPTB variant<\/jats:italic>\n                      and a family history of neonatal bilirubin toxicity. Fetal surveillance was unremarkable, and the neonate had no hematologic complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This series illustrates the diverse courses of pregnancies at risk of HS. While MCA Doppler ultrasound is a valuable surveillance tool to identify fetal anemia, our findings suggest that MCA Doppler values alone may not reliably predict postnatal severity. In pregnancies at risk of HS, consideration of maternal and family history, genetic evaluation, and serial surveillance remains essential for prenatal counseling and perinatal planning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70185","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T10:43:44Z","timestamp":1779533024000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hereditary Spherocytosis: A Case Series Spanning Prenatal Detection to Neonatal Care"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8439-9386","authenticated-orcid":false,"given":"Carly M.","family":"Smith","sequence":"first","affiliation":[{"name":"Fetal and Pregnancy Health Program Stanford Medicine Children's Health  Palo Alto California USA"},{"name":"Department of Pediatrics Division of Medical Genetics Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra M.","family":"Dinu","sequence":"additional","affiliation":[{"name":"College of Osteopathic Medicine Pacific Northwest University of Health Sciences  Yakima Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan R.","family":"Hintz","sequence":"additional","affiliation":[{"name":"Fetal and Pregnancy Health Program Stanford Medicine Children's Health  Palo Alto California USA"},{"name":"Department of Pediatrics Division of Neonatology and Developmental Medicine Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen C.","family":"Minor","sequence":"additional","affiliation":[{"name":"Fetal and Pregnancy Health Program Stanford Medicine Children's Health  Palo Alto California USA"},{"name":"Department of Obstetrics &amp; Gynecology Division of Maternal\u2010Fetal Medicine and Obstetrics Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Foley","sequence":"additional","affiliation":[{"name":"Fetal and Pregnancy Health Program Stanford Medicine Children's Health  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Weigel","sequence":"additional","affiliation":[{"name":"Fetal and Pregnancy Health Program Stanford Medicine Children's Health  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertil E.","family":"Glader","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology\/Oncology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yair J.","family":"Blumenfeld","sequence":"additional","affiliation":[{"name":"Fetal and Pregnancy Health Program Stanford Medicine Children's Health  Palo Alto California USA"},{"name":"Department of Obstetrics &amp; Gynecology Division of Maternal\u2010Fetal Medicine and Obstetrics Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(08)61588\u20103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001063420102"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000456661"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2013.04.003"},{"issue":"1","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/cge.12749","article-title":"Mutational Characteristics of ANK1 and SPTB Genes in Hereditary Spherocytosis","volume":"90","author":"Park J.","year":"2016","journal-title":"Clinical Genetics"},{"key":"e_1_2_9_6_2","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/cge.12749.","DOI":"10.1111\/cge.12749"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000276"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/exmp.2001.2377"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2009.08.011"},{"issue":"1","key":"e_1_2_9_10_1","article-title":"Fetal SPTA1\u2010related Hemolytic Anemia Presenting in the Mid\u2010Trimester With Ascites","volume":"4","author":"Singh K.","year":"2023","journal-title":"Pediatrics & Neonatology"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17617"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crwh.2017.09.003"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.652376"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.00953"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s10038\u2010020\u20100724\u2010z"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20273"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.280799"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.70185","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.70185","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.70185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T10:43:46Z","timestamp":1779533026000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.70185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,23]]},"references-count":17,"alternative-id":["10.1002\/pd.70185"],"URL":"https:\/\/doi.org\/10.1002\/pd.70185","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,23]]},"assertion":[{"value":"2026-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"pd.70185"}}