{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T14:48:29Z","timestamp":1782053309799,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the feasibility and clinical value of implementing first\u2010trimester molecular HPA screening to identify pregnancies at risk for FNAIT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective cohort study, pregnant women were genotyped during the first trimester for HPA\u20101, \u20102, \u20103, \u20104, \u20105, \u20106, \u20109, and \u201015 using molecular methods. When low\u2010frequency maternal genotypes were identified, paternal genotyping and risk stratification were performed to assess maternal\u2013fetal incompatibility. At\u2010risk pregnancies underwent structured clinical monitoring, and neonatal platelet counts were obtained at birth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 200 screened pregnancies, three (1.5%) were HPA\u20101b\/1b. Prenatal screening identified five pregnancies at risk for FNAIT: three involving HPA\u20101, one HPA\u20103, and one HPA\u201015 incompatibility. Two neonates required compatible platelet transfusions. Early detection allowed anticipatory perinatal management and facilitated timely transfusion support when indicated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>First\u2010trimester molecular HPA screening is feasible and enables an early identification of pregnancies at risk for FNAIT across multiple antigen systems, allowing for appropriate clinical interventions. These findings support the potential role of targeted prenatal screening programs in improving the recognition and management of FNAIT, even in populations with a low prevalence of HPA\u20101a\u2013negative women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70203","type":"journal-article","created":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T14:18:31Z","timestamp":1782051511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["First\u2010Trimester Molecular Screening for Fetal and Neonatal Alloimmune Thrombocytopenia: Early Identification of At\u2010Risk Pregnancies"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7832-2833","authenticated-orcid":false,"given":"Sebasti\u00e1n","family":"Blanco","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n Banco Central de Sangre  C\u00f3rdoba Argentina"},{"name":"Facultad de Ciencias de la Salud Universidad Cat\u00f3lica de C\u00f3rdoba  C\u00f3rdoba Argentina"},{"name":"Facultad de Ciencias M\u00e9dicas Instituto de Virolog\u00eda Dr. J. M. Vanella Universidad Nacional de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Horacio","family":"Carrizo","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Banco Central de Sangre  C\u00f3rdoba Argentina"},{"name":"Maternidad Provincial Ra\u00fal Felipe Lucini Ministerio de Salud  C\u00f3rdoba Argentina"},{"name":"Maternidad Provincial Brigadier Juan Bautista Bustos Ministerio de Salud  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Lazarte","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Banco Central de Sangre  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Carina","family":"Vega","sequence":"additional","affiliation":[{"name":"Maternidad Provincial Ra\u00fal Felipe Lucini Ministerio de Salud  C\u00f3rdoba Argentina"},{"name":"Maternidad Provincial Brigadier Juan Bautista Bustos Ministerio de Salud  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Mario","family":"Culaso","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Banco Central de Sangre  C\u00f3rdoba Argentina"},{"name":"Maternidad Provincial Ra\u00fal Felipe Lucini Ministerio de Salud  C\u00f3rdoba Argentina"},{"name":"Maternidad Provincial Brigadier Juan Bautista Bustos Ministerio de Salud  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Ver\u00f3nica","family":"Gallego","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Banco Central de Sangre  C\u00f3rdoba Argentina"},{"name":"Facultad de Ciencias M\u00e9dicas Instituto de Virolog\u00eda Dr. J. 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Vanella Universidad Nacional de C\u00f3rdoba  C\u00f3rdoba Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000547985"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2025.102683"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13779"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S90753"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2015.12.004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12235"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12450"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13550"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471\u20100528.15642"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201010\u2010739656"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12379"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2017.1346471"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13274"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2450\/2020.0018\u201020"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20103148.2007.00819.x"},{"issue":"1","key":"e_1_2_10_17_1","first-page":"15","article-title":"Fetal and Neonatal Alloimmune Thrombocytopenia","volume":"6","author":"Espinoza J. 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