{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T10:40:32Z","timestamp":1792752032690,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Pregnancy loss affects approximately 15% of pregnancies worldwide, with genetic abnormalities being a major cause. This study aimed to investigate the genetic etiologies of pregnancy loss in Vietnam and to characterize associated clinical features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      This retrospective study included 636 pregnancy loss cases from a multicenter Vietnamese cohort across 18 centers (2022\u20132024). Products of conception were analyzed using copy number variant sequencing (CNV\u2010seq,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0636) and clinical exome sequencing (CES,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0401).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Genetic etiologies were identified in 209 of 636 cases (32.9%). Numerical chromosomal abnormalities accounted for 27%, structural abnormalities for 3%, and single\u2010gene variants for 2%. Sixteen pathogenic variants in 12 genes were detected, with\n                      <jats:italic>FGFR3<\/jats:italic>\n                      and skeletal dysplasia being the most common monogenic finding. CNV\u2010seq and CES detected abnormalities in 30.7% and 3.5% of cases, respectively. Among cases with identified genetic anomalies, 71.3% presented with early pregnancy loss (\u2264 12\u00a0weeks), 47.4% had a history of prior pregnancy loss, 31.1% were of advanced maternal age.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides a preliminary descriptive analysis of genetic causes of pregnancy loss in a Vietnamese cohort. The application of CNV\u2010seq and CES may be helpful in identifying genetic causes and can help inform the management of future pregnancies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70215","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:40:16Z","timestamp":1783921216000},"page":"1760-1770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Etiology of Miscarriage in a Vietnamese Cohort Using CNV\u2010Seq and Exome Sequencing"],"prefix":"10.1002","volume":"46","author":[{"given":"Minh Doan","family":"Thai","sequence":"first","affiliation":[{"name":"HOPE Research Center\u2014My Duc Hospital  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khanh Vu","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute  Ho Chi Minh City Vietnam"},{"name":"Gene Solutions  Ho\u00a0Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u2010Thanh","family":"Lu","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thu\u2010Hang","family":"Le Nguyen","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute  Ho Chi Minh City Vietnam"},{"name":"Gene Solutions  Ho\u00a0Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh Ngoc","family":"Phan","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute  Ho Chi Minh City Vietnam"},{"name":"Gene Solutions  Ho\u00a0Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huong","family":"Van Pham","sequence":"additional","affiliation":[{"name":"Andrology and Fertility Hospital of Hanoi  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trung Thanh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Andrology and Fertility Hospital of Hanoi  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoa Thi","family":"Phuong Bui","sequence":"additional","affiliation":[{"name":"Andrology and Fertility Hospital of Hanoi  Hanoi Vietnam"},{"name":"Thai Binh University of Medicine and Pharmacy  Thai Binh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan\u2010Anh","family":"Thi Luong","sequence":"additional","affiliation":[{"name":"Hanoi Medical University  Hanoi Vietnam"},{"name":"Hanoi Medical University Hospital  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuong Hong","family":"Duong","sequence":"additional","affiliation":[{"name":"Hanoi Obstetrics and Gynecology Hospital  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7746-5976","authenticated-orcid":false,"given":"Sim Thi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Phenikaa University Hospital  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Son","family":"Van Hoang","sequence":"additional","affiliation":[{"name":"Hanoi Medical University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai\u2010Anh","family":"Thi Pham","sequence":"additional","affiliation":[{"name":"Hai Phong Obstetrics and Gynecology Hospital  Hai Phong Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Son Ta","family":"Vo","sequence":"additional","affiliation":[{"name":"Vinmec International Hospital  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc\u2010Ha","family":"Thi Tran","sequence":"additional","affiliation":[{"name":"Nghe An Obstetrics and Pediatrics Hospital  Vinh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thu Huong","family":"Nhut Trinh","sequence":"additional","affiliation":[{"name":"Tu Du Hospital  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3803-9472","authenticated-orcid":false,"given":"Thi Minh","family":"Thi Ha","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy Hue University  Hue City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhat\u2010Thang","family":"Tran","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy at Ho Chi Minh City  Ho\u00a0Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9202-1092","authenticated-orcid":false,"given":"Van Thong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Hung Vuong Hospital  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quang Thanh","family":"Le","sequence":"additional","affiliation":[{"name":"Tu Du Hospital  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diem\u2010Tuyet","family":"Thi Hoang","sequence":"additional","affiliation":[{"name":"Hung Vuong Hospital  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"My\u2010Nhi","family":"Ba Nguyen","sequence":"additional","affiliation":[{"name":"Tam Anh General Hospital  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen Nhi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute  Ho Chi Minh City Vietnam"},{"name":"Gene Solutions  Ho\u00a0Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linh Trang","family":"Le","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute  Ho Chi Minh City Vietnam"},{"name":"Gene Solutions  Ho\u00a0Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung Son","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute  Ho Chi Minh City Vietnam"},{"name":"Gene Solutions  Ho\u00a0Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thien\u2010Phuc","family":"Hoang Nguyen","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute  Ho Chi Minh City Vietnam"},{"name":"Gene Solutions  Ho\u00a0Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinh\u2010Kiet","family":"Truong","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute  Ho Chi Minh City Vietnam"},{"name":"Gene Solutions  Ho\u00a0Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh\u2010Thuy","family":"Thi Do","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute  Ho Chi Minh City Vietnam"},{"name":"Gene Solutions  Ho\u00a0Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uyen Vu","family":"Tran","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute  Ho Chi Minh City Vietnam"},{"name":"Gene Solutions  Ho\u00a0Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duy Minh","family":"Phan","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute  Ho Chi Minh City Vietnam"},{"name":"Gene Solutions  Ho\u00a0Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuong Manh","family":"Ho","sequence":"additional","affiliation":[{"name":"HOPE Research Center\u2014My Duc Hospital  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoai\u2010Nghia","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute  Ho Chi Minh City Vietnam"},{"name":"Gene Solutions  Ho\u00a0Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoa","family":"Giang","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute  Ho Chi Minh City Vietnam"},{"name":"Gene Solutions  Ho\u00a0Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8484-4954","authenticated-orcid":false,"given":"Hung\u2010Sang","family":"Tang","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute  Ho Chi Minh City Vietnam"},{"name":"Gene Solutions  Ho\u00a0Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deae008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(21)00682\u20106"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoad002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.08.952"},{"key":"e_1_2_10_6_1","volume-title":"Statpearls. Treasure Island (FL) Ineligible Companies","author":"Alves C.","year":"2024"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13039\u2010024\u201000671\u20107"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102105\u201010\u201080"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2005.045179"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.73"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2020.1849126"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40291\u2010021\u201000523\u20109"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404\u2010020\u201005859\u2010x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.03.004"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.2.446"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.07.276"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366\u20106999.167352"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10038\u2010004\u20100164\u20101"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.12659\/msm.881969"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgg.2016.02.002"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293\u2010020\u201000299\u20103"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijwh.S20557"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010020\u201001008\u20106"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.9201"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaw008"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201086309\u20109"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010021\u201003202\u20109"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/134166"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.5001"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2024.03.005"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.3219"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2022.12.026"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/children9040530"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36838"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23791"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908753"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.14333"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1195222"},{"issue":"2","key":"e_1_2_10_39_1","first-page":"85","article-title":"From Childhood Onset Lymphedema to Fatal Fetal Hydrops: Possible Modifying Genes for a FOXC2 Mutation","volume":"51","author":"Lai L. W.","year":"2018","journal-title":"Lymphology"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1086\/316915"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2011.09.027"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.51.8.618"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1515\/medgen\u20102021\u20102051"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.10.102"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741\u20107015\u201011\u2010154"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.70215","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.70215","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.70215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T10:00:28Z","timestamp":1792749628000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.70215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,12]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/pd.70215"],"URL":"https:\/\/doi.org\/10.1002\/pd.70215","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,12]]},"assertion":[{"value":"2026-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}