{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T18:04:07Z","timestamp":1789322647109,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe diagnostic trajectories and parental decision\u2010making following increased first\u2010trimester nuchal translucency (NT), according to NT thickness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This 12\u2010year retrospective cohort study was conducted at a French tertiary Prenatal Diagnosis and Fetal Medicine Center and included 316 singleton pregnancies with first\u2010trimester NT\u00a0\u2265\u00a03.5\u00a0mm, with or without structural anomalies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Termination of pregnancy occurred in 180\/316 pregnancies (57.0%), while 91\/316 (28.8%) resulted in live birth without pathology. TOP without prior invasive prenatal testing increased from 7.4% in the 3.5\u2013&lt; 5.0\u00a0mm group to 35.0% in the \u2265 6.5\u00a0mm group. Invasive prenatal testing was performed in 248 pregnancies. Among 137 pregnancies with an abnormal genetic result and known outcome, 12 (8.8%) were continued. Structural ultrasound assessment was performed in 111 pregnancies; 17\/29 (58.6%) with abnormal findings were continued. Among 51 pregnancies that continued after normal genetic testing and normal structural ultrasound, 42 (82.4%) resulted in live birth without pathology at the last follow\u2010up, including 3\/8 (37.5%) with NT\u00a0\u2265\u00a06.5\u00a0mm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Parental decisions and outcomes varied with NT thickness. Integrating NT measurements with sequential genetic and ultrasound findings may support individualized prenatal counseling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70224","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:50:59Z","timestamp":1784094659000},"page":"1520-1528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Parental Decision\u2010Making and Pregnancy Outcomes After Increased First\u2010Trimester Nuchal Translucency: A 12\u2010Year Cohort"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9472-9334","authenticated-orcid":false,"given":"Benjamin","family":"Birene","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Department Centre Hospitalier Universitaire de Reims  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Paul","family":"Bory","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Centre Hospitalier Universitaire de Reims  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloi","family":"Dondeyne","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Centre Hospitalier Universitaire de Reims  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Charbonneau","sequence":"additional","affiliation":[{"name":"Paediatric and Congenital Cardiology Unit Centre Hospitalier Universitaire de Reims  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8195-0507","authenticated-orcid":false,"given":"Cl\u00e9mence","family":"Jacquin","sequence":"additional","affiliation":[{"name":"Genetics Department Centre Hospitalier Universitaire de Reims  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Landais","sequence":"additional","affiliation":[{"name":"Genetics Department Centre Hospitalier Universitaire de Reims  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Dakin","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Centre Hospitalier Universitaire de Reims  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Graesslin","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Centre Hospitalier Universitaire de Reims  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.093"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.03.090"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.3689"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469\u20100705.1998.11060401.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6024"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203382"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)31940\u20108"},{"key":"e_1_2_12_9_1","unstructured":"Article R2131\u201010\u20101\u2014Code de la sant\u00e9 publique\u2014L\u00e9gifrance. 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