{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:06:10Z","timestamp":1791378370461,"version":"4.3.2"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the overall diagnostic yield of sequential chromosomal microarray (CMA) and exome sequencing (ES) across the phenotypic spectrum of fetal growth restriction (FGR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort of 320 consecutive FGR pregnancies presenting at \u2265\u00a020\u00a0weeks to a tertiary fetal medicine unit (2020\u20132025). All patients underwent a dedicated anatomical survey, including neurosonography. Cases were classified as isolated or non\u2010isolated and characterized by organ system, severity, gestational age at onset, and Doppler status. Genetic counseling was offered to all patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      FGR was isolated in 199\/320 (62.2%) and non\u2010isolated in 121\/320 (37.8%); 218\/320 (68.1%) were early\u2010onset (&lt; 32\u00a0weeks) and 96\/320 (30%) had abnormal Doppler. CMA was performed in 237\/320 (74.1%), yielding an abnormality in 5.5% (13\/237). Of these, only 5\/237 (2.1%) were considered causative of the FGR phenotype. ES was performed in 149\/320 (46.6%), with an overall FGR\u2010causative yield of 10.7% (16\/149), significantly higher in non\u2010isolated versus isolated cases (18.5% vs. 4.8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.014). Abnormal Doppler did not preclude a monogenic diagnosis (5\/16 FGR\u2010causative cases).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FGR carries a substantial genetic yield, supporting stratified testing across the phenotypic spectrum. A monogenic diagnosis and placental vascular disease are not mutually exclusive. A molecular etiology provides information for counseling, recurrence\u2010risk assessment, and reproductive planning, regardless of outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.70258","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:45:11Z","timestamp":1791377111000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Isolated to Complex: Diagnostic Yield of Chromosomal Microarray and Exome Sequencing in Fetal Growth Restriction"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9941-0215","authenticated-orcid":false,"given":"Hadas","family":"Miremberg","sequence":"first","affiliation":[{"name":"Division of Obstetric Ultrasound Lis Maternity Hospital Tel Aviv Sourasky University Medical Center  Tel Aviv Israel"},{"name":"Gray Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May","family":"Shabat","sequence":"additional","affiliation":[{"name":"Division of Obstetric Ultrasound Lis Maternity Hospital Tel Aviv Sourasky University Medical Center  Tel Aviv Israel"},{"name":"Gray Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Stok","sequence":"additional","affiliation":[{"name":"Division of Obstetric Ultrasound Lis Maternity Hospital Tel Aviv Sourasky University Medical Center  Tel Aviv Israel"},{"name":"Faculty of Health Sciences, Joyce &amp; Irving Goldman Medical School Ben Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vered Offer","family":"Glasner","sequence":"additional","affiliation":[{"name":"Genetics Institute &amp; Genome Center Tel Aviv Sourasky University Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2754-459X","authenticated-orcid":false,"given":"Adi","family":"Botvinik","sequence":"additional","affiliation":[{"name":"Genetics Institute &amp; Genome Center Tel Aviv Sourasky University Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mordechai","family":"Shohat","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Maccabi Genetic Institute &amp; Bioinformatics Unit Sheba Cancer Research Center  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2915-3732","authenticated-orcid":false,"given":"Michal","family":"Levy","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Genetics Institute &amp; Genome Center Tel Aviv Sourasky University Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8622-7668","authenticated-orcid":false,"given":"Yuval","family":"Yaron","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Genetics Institute &amp; Genome Center Tel Aviv Sourasky University Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1073-6348","authenticated-orcid":false,"given":"Roee","family":"Birnbaum","sequence":"additional","affiliation":[{"name":"Division of Obstetric Ultrasound Lis Maternity Hospital Tel Aviv Sourasky University Medical Center  Tel Aviv Israel"},{"name":"Gray Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8023-0679","authenticated-orcid":false,"given":"Sharon","family":"Perlman","sequence":"additional","affiliation":[{"name":"Division of Obstetric Ultrasound Lis Maternity Hospital Tel Aviv Sourasky University Medical Center  Tel Aviv Israel"},{"name":"Gray Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0864-206X","authenticated-orcid":false,"given":"Gustavo","family":"Malinger","sequence":"additional","affiliation":[{"name":"Division of Obstetric Ultrasound Lis Maternity Hospital Tel Aviv Sourasky University Medical Center  Tel Aviv Israel"},{"name":"Gray Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9868-3548","authenticated-orcid":false,"given":"Karina Krajden","family":"Haratz","sequence":"additional","affiliation":[{"name":"Division of Obstetric Ultrasound Lis Maternity Hospital Tel Aviv Sourasky University Medical Center  Tel Aviv Israel"},{"name":"Gray Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15884"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.05.010"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13522"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23664"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.12.004"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22134"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.70022"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6339"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.09.045"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2025.101809"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.181.1.1887021"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2023.1032346"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010019\u20100686\u20108"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2217405120"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2021.09.009"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2013.00190"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddz174"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.4161\/org.6.2.11687"},{"issue":"2","key":"e_1_2_11_21_1","first-page":"455","article-title":"Vascular Endothelial Growth Factor (VEGF) \u2013 Key Factor in Normal and Pathological Angiogenesis","volume":"59","author":"Melincovici C. 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