{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:44:41Z","timestamp":1780983881691,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2003,11,28]],"date-time":"2003-11-28T00:00:00Z","timestamp":1069977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2003,12,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To audit diagnostic and therapeutic fetal cystoscopy for suspected posterior urethral valves (PUV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 13 fetuses, (14\u201328 weeks) the bladder was entered with a 1.3 mm embryo\u2010fetoscope and intravesical findings documented. In 10 fetuses, an attempt was made to treat the obstruction by saline hydro\u2010ablation (<jats:italic>n<\/jats:italic> = 4) and\/or guide\u2010wire passage (<jats:italic>n<\/jats:italic> = 9). Renal function was assessed post\u2010natally at 10 to 34 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The bladder wall was visualised in 12\/13 cases and the bladder neck in 11; in 10 cases the upper urethra was entered, and the obstruction visualised in five. PUV were \u2018seen\u2019 in 4\/9 confirmed cases, but also in one case of urethral atresia, while in two others the degree of resistance to guide\u2010wire passage suggested atresia or prune belly. Therapeutic attempts were technically successful, at least initially, in 6\/10 cases. Of the five cases with confirmed PUV and normal fetal urinary electrolytes, two have acceptable renal function at follow\u2010up. Hydro\u2010ablation in one case resulted in resolution of sonographic signs of obstruction, and ablated valves were confirmed post\u2010natally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Semi\u2010rigid fetal cystoscopy allows entry into the upper urethra in most obstructive uropathies, although bladder neck angulation precludes visualisation of the site of obstruction in the majority. Guide\u2010wire passage or hydro\u2010ablation may allow relatively atraumatic ablation of PUV <jats:italic>in utero<\/jats:italic> without the chronic bladder decompression associated with vesico\u2010amniotic shunting. However, current technical limitations need to be overcome, possibly by the use of flexible or angled fetoscopes, before the role of cystoscopic treatment can be formally evaluated. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.717","type":"journal-article","created":{"date-parts":[[2003,12,18]],"date-time":"2003-12-18T08:00:47Z","timestamp":1071734447000},"page":"1033-1041","source":"Crossref","is-referenced-by-count":89,"title":["Fetal cystoscopy in the management of fetal obstructive uropathy: experience in a single European centre"],"prefix":"10.1002","volume":"23","author":[{"given":"Alec","family":"Welsh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sailesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Fisk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,11,28]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000020834"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00307.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.226"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64761-X"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00858690"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92567-0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)11006-1"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(82)80476-4"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(83)80094-3"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.1.e7"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-199904000-00011"},{"key":"e_1_2_1_13_1","first-page":"394","volume-title":"The Unborn Patient: Prenatal Diagnosis and Treatment","author":"Manning F","year":"1991"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1992.tb14391.x"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)37865-5"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90115-9"},{"key":"e_1_2_1_17_1","first-page":"208","article-title":"In utero endoscopic treatment of posterior urethral valves: preliminary experience","volume":"3","author":"Quintero RA","year":"1998","journal-title":"Prenat Neonatal Med"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91381-5"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.717","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T19:00:09Z","timestamp":1700247609000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,28]]},"references-count":17,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2003,12,30]]}},"alternative-id":["10.1002\/pd.717"],"URL":"https:\/\/doi.org\/10.1002\/pd.717","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11,28]]}}}