{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:09:26Z","timestamp":1777496966440,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2003,12,2]],"date-time":"2003-12-02T00:00:00Z","timestamp":1070323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2003,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To find whether f\u03b2hCG, PAPP\u2010A and inhibin\u2010A levels in maternal serum or fetal nuchal translucency (NT) thickness at the first\u2010trimester screening for trisomy 21 (T21) might detect women at high risk for adverse pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of 1136 women with singleton pregnancy between 10 and 14 weeks. Women with pregnancy complications were allotted to five subgroups: small for gestational age (SGA), large for gestational age (LGA), gestational diabetes (GDM), hypertensive disorders, preterm delivery; women with normal pregnancy represented the control group. NT, maternal serum f\u03b2hCG, PAPP\u2010A and inhibin\u2010A were measured. Mann\u2013Whitney test was used for the comparison of f\u03b2hCG, PAPP\u2010A, inhibin\u2010A and NT between a subgroup of a certain pregnancy complication and the control group. Multivariate logistic regression models were built to explore the relationship among different variables and the occurrence of pregnancy complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PAPP\u2010A values were significantly lower in women who delivered SGA babies (<jats:italic>n<\/jats:italic> = 51, 0.76 MoM; <jats:italic>p<\/jats:italic> = 0.002) and significantly higher in women who delivered LGA babies (<jats:italic>n<\/jats:italic> = 120, 1.12 MoM; <jats:italic>p<\/jats:italic> = 0.036). In women with GDM (<jats:italic>n<\/jats:italic> = 27), f\u03b2hCG, PAPP\u2010A and inhibin\u2010A were insignificantly lower than in controls, whereas in women with hypertensive disorders (<jats:italic>n<\/jats:italic> = 56) no significant differences between the groups were found. In women with a preterm delivery (&lt;34 weeks) (<jats:italic>n<\/jats:italic> = 17), inhibin\u2010A levels were significantly higher (1.25 MoM; <jats:italic>p<\/jats:italic> = 0.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low PAPP\u2010A level is associated with the delivery of an SGA baby and high PAPP\u2010A with the delivery of an LGA baby. High inhibin\u2010A is associated with preterm delivery before 34 weeks. Feto\u2010placental products in the first trimester do not prove to be useful as a screening tool for predicting pregnancy complications. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.735","type":"journal-article","created":{"date-parts":[[2003,12,4]],"date-time":"2003-12-04T08:00:38Z","timestamp":1070524838000},"page":"990-996","source":"Crossref","is-referenced-by-count":101,"title":["Predicting complications of pregnancy with first\u2010trimester maternal serum free\u2010\u03b2hCG, PAPP\u2010A and inhibin\u2010A"],"prefix":"10.1002","volume":"23","author":[{"given":"Nata\u0161a","family":"Tul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanko","family":"Pu\u0161enjak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u0161ko","family":"Osredkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u017diva","family":"Novak\u2010Antoli\u010d","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,12,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199605093341904"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970120804"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(83)90013-0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(98)00024-0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(200003)20:3<186::AID-PD776>3.0.CO;2-A"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.5.1548"},{"key":"e_1_2_1_8_1","first-page":"83","article-title":"The association between unexplained second\u2010trimester serum hCG elevation and pregnancy complications","volume":"80","author":"Gonen R","year":"1992","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970140416"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30086-1"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a137965"},{"key":"e_1_2_1_12_1","first-page":"249","article-title":"Insulin like growth factors. 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