{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T19:10:25Z","timestamp":1700248225537},"reference-count":11,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2003,11,4]],"date-time":"2003-11-04T00:00:00Z","timestamp":1067904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2003,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>While chromosomal abnormalities are often the cause of early failed pregnancies, other mechanisms could be involved in monochorionic twin intrauterine deaths, that might be screened for careful morphological analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Transcervical fetoscopy prior to instrumental evacuation of the uterus was performed in four first\u2010trimester monochorionic twin intrauterine deaths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We present fetoscopic and cytogenetic findings in four cases of monochorionic twin intrauterine deaths. In the first, generalized abnormal embryonic development observed in both twins was a manifestation of trisomy 20. The second (thoracophagus) and third (acardius) pair of twins had anomalies peculiar to multiple gestations. The fourth pair of twins was remarkable because of the concordance for the observed limb\u2010reduction defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Malformations of first\u2010trimester monochorionic twin intrauterine deaths might cover a wide spectrum of etiologies from abnormal chromosomes and single gene defects to rare duplication anomalies. Their detection by careful morphological analysis and the identification of a specific mechanism provides valuable information for genetic counseling and prenatal investigation in a future pregnancy. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.736","type":"journal-article","created":{"date-parts":[[2003,12,4]],"date-time":"2003-12-04T08:00:38Z","timestamp":1070524838000},"page":"964-969","source":"Crossref","is-referenced-by-count":4,"title":["Transcervical fetoscopic diagnosis of structural defects in four first\u2010trimester monochorionic twin intrauterine deaths"],"prefix":"10.1002","volume":"23","author":[{"given":"T.","family":"Philipp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. R.","family":"Separovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Philipp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Reiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. K.","family":"Kalousek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,11,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-9514-0_7"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.14030153.x"},{"key":"e_1_2_1_4_1","first-page":"334","volume-title":"Development Pathology of the Embryo & Fetus","author":"Dimmick JE","year":"1992"},{"key":"e_1_2_1_5_1","first-page":"53","article-title":"Early spontaneous abortion: morphologic and karyotypic findings in 3912 cases","volume":"29","author":"Kalousek DK","year":"1993","journal-title":"Birth Defects"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420210202"},{"key":"e_1_2_1_7_1","first-page":"708","article-title":"The acardiac monster. A review of the world literature and presentation of two cases","volume":"82","author":"Napolitani FD","year":"1960","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016666301481"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.150"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10476"},{"key":"e_1_2_1_11_1","first-page":"5","article-title":"Spontaneous abortion: a study of 1961 women and their conceptuses","volume":"102","author":"Poland BJ","year":"1981","journal-title":"Acta Obstet Gynecol Scand Suppl"},{"key":"e_1_2_1_12_1","first-page":"465","article-title":"Does the karyotype of a spontaneous abortion predict the karyotype of a subsequent abortion?\u2010evidence from 273 women with two karyotyped spontaneous abortions","volume":"41","author":"Warburton D","year":"1987","journal-title":"Am J Hum Genet"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.736","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T18:49:18Z","timestamp":1700246958000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,4]]},"references-count":11,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2003,12,15]]}},"alternative-id":["10.1002\/pd.736"],"URL":"https:\/\/doi.org\/10.1002\/pd.736","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11,4]]}}}