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Karyotype of the fetus revealed 45,XX,der(15;18)(q10;q10) in all metaphases. The targeted fetal ultrasound at 20 weeks of gestation did not show any special physical abnormalities other than 6.4 mm of nuchal fold thickness. Molecular cytogenetic findings using CGH and FISH confirmed the del(18p) with dicentromeres from both chromosome 15 and 18. The present study shows that the INT at first trimester was the only prenatal finding for the fetus with del(18p) syndrome and that molecular cytogenetic methods are useful for detecting chromosomal aberrations precisely. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pd.741","type":"journal-article","created":{"date-parts":[[2004,3,29]],"date-time":"2004-03-29T08:03:07Z","timestamp":1080547387000},"page":"161-164","source":"Crossref","is-referenced-by-count":13,"title":["Del(18p) syndrome with increased nuchal translucency in prenatal diagnosis"],"prefix":"10.1002","volume":"24","author":[{"given":"Young\u2010Mi","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun\u2010Hee","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Mi","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon\u2010Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So\u2010Yeon","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun\u2010Mee","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7176.81a"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.63"},{"key":"e_1_2_1_4_1","first-page":"1028","article-title":"Dysmorphic complexe avec oligophrenie: deletion des bras courts d'un chromosome 18","volume":"256","author":"de Grouchy J","year":"1963","journal-title":"C R Acad Sci III"},{"issue":"2","key":"e_1_2_1_5_1","first-page":"94","article-title":"Dissociation of tdic chromosomes: about a t(15;18)(p11;p11) leading to 18p monosomy","volume":"30","author":"Garcia\u2010Esquivel L","year":"1987","journal-title":"Ann Genet"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.6.2156"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1359641"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2001.590410.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.16.5.399"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1994.tb11946.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92240-G"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.05010015.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-3995(01)01085-1"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1584"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00125817-200201000-00003"},{"key":"e_1_2_1_16_1","volume-title":"Catalogue of Unbalanced Chromosome Aberrations in Man","author":"Schinzel A","year":"2001"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199806)18:6<581::AID-PD301>3.0.CO;2-6"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1977.tb01325.x"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1996.07030216.x"},{"issue":"3","key":"e_1_2_1_20_1","first-page":"158","article-title":"18p monosomy with midline defects and a de novo satellite identified by FISH","volume":"40","author":"Taine L","year":"1997","journal-title":"Ann Genet"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320400125"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20010215)99:1<67::AID-AJMG1118>3.0.CO;2-V"},{"key":"e_1_2_1_23_1","volume-title":"Human Chromosomes. 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