{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T22:18:41Z","timestamp":1775686721448,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,3,30]],"date-time":"2004-03-30T00:00:00Z","timestamp":1080604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the natural history of the prenatal development of ventriculomegaly and talipes in fetuses with open <jats:italic>spina bifida<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>All fetuses with isolated open <jats:italic>spina bifida<\/jats:italic> and managed at our center between January 1996 and March 2000 were retrospectively evaluated. Ultrasonographic images and reports were reviewed from examinations performed every 3 to 4 weeks from the time of diagnosis to delivery for lesion level and type, ventriculomegaly (defined as an atrial width of \u226510 mm), and lower extremity appearance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 53 pregnancies identified, 20 (38%) were electively terminated. In the 33 ongoing gestations, the lesions ranged from lower thoracic to sacral; 79% were characterized as meningomyeloceles and 21% as myeloschises. Fifty\u2010five percent (<jats:italic>n<\/jats:italic> = 18) had ventriculomegaly at diagnosis (early onset, mean gestational age at diagnosis 22 \u00b1 5 weeks), 33% (<jats:italic>n<\/jats:italic> = 11) subsequently developed ventriculomegaly (late onset, mean 29 \u00b1 6 weeks), and 12% (<jats:italic>n<\/jats:italic> = 4) had normal ventricle size at the last sonogram before birth (mean 38 \u00b1 1 weeks). The ventricular size prior to delivery was significantly smaller with late\u2010onset ventriculomegaly than with early\u2010onset: 15 \u00b1 4 mm versus 28 \u00b1 10 mm, (<jats:italic>p<\/jats:italic> = 0.001). Only 6% (<jats:italic>n<\/jats:italic> = 2) had talipes at the initial sonogram, and 18% (<jats:italic>n<\/jats:italic> = 6) were subsequently determined to have talipes (mean 30 \u00b1 6 weeks).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Most fetuses with open <jats:italic>spina bifida<\/jats:italic> develop ventriculomegaly, and the majority do so by 21 weeks' gestation. Fetuses that develop ventriculomegaly later in gestation have less severe ventricular dilation at birth. In contrast, a minority of fetuses have congenital talipes, and because most cases develop after 20 weeks, they are not predicted by early midtrimester sonographic evaluation. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.853","type":"journal-article","created":{"date-parts":[[2004,3,30]],"date-time":"2004-03-30T11:53:45Z","timestamp":1080647625000},"page":"287-289","source":"Crossref","is-referenced-by-count":33,"title":["Fetal open <i>spina bifida<\/i>: a natural history of disease progression <i>in utero<\/i>"],"prefix":"10.1002","volume":"24","author":[{"suffix":"Jr","given":"Joseph R.","family":"Biggio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharine D.","family":"Wenstrom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Owen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,3,30]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.190.3.8115615"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1071245"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911113412006"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.19.1819"},{"key":"e_1_2_1_6_1","first-page":"635","volume-title":"Genetic Disorders and the Fetus: Diagnosis, Prevention, and Treatment","author":"Milunsky A","year":"1998"},{"key":"e_1_2_1_7_1","first-page":"36","volume-title":"Prenatal Diagnosis of Congenital Anomalies","author":"Romero R","year":"1988"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.19.1826"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000028859"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.853","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T17:09:41Z","timestamp":1700240981000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3,30]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1002\/pd.853"],"URL":"https:\/\/doi.org\/10.1002\/pd.853","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3,30]]}}}