{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:53:24Z","timestamp":1767844404832,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,5,21]],"date-time":"2004-05-21T00:00:00Z","timestamp":1085097600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate fetal serum \u00df2\u2010microglobulin and cystatin C in the prediction of post\u2010natal renal function in bilateral hypoplasia and hyperechogenic enlarged kidneys. Predicting post\u2010natal renal function is crucial to the prenatal evaluation of fetal nephropathies. Prenatal ultrasound can identify terminal renal failure, but is not sensitive enough to identify infants whose post\u2010natal renal function will be impaired. Fetal serum \u00df2\u2010microglobulin and cystatin C are potential predictors of post\u2010natal renal function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010four prenatally diagnosed cases of bilateral nephropathy were retrospectively reviewed. Final diagnosis was established using histological or post\u2010natal findings: renal hypoplasia (<jats:italic>n<\/jats:italic> = 7), cystic dysplasia (<jats:italic>n<\/jats:italic> = 9), autosomal dominant polycystic kidney disease (ADPKD; <jats:italic>n<\/jats:italic> = 8) or autosomal recessive polycystic kidney disease (ARPKD; <jats:italic>n<\/jats:italic> = 22) and transient sonographic abnormalities (<jats:italic>n<\/jats:italic> = 8). Fetal serum \u00df2\u2010microglobulin and cystatin C were assayed respectively in 54 and 38 cases. The prognostic value of these markers was assessed in terms of the post\u2010natal outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In bilateral kidney hypoplasia and cystic dysplasia, \u00df2\u2010microglobulin and cystatin C were significantly (<jats:italic>p<\/jats:italic> &lt; 0.0001 and <jats:italic>p<\/jats:italic> &lt; 0.02 respectively) higher than in the normal control group. In hyperechogenic fetal kidneys (ARPKD, ADPKD and transient sonographic abnormalities), these markers were not different from controls. However, whereas normal values cannot exclude renal failure, abnormal values predict post\u2010natal renal failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In bilateral renal hypoplasia and dysplasia, fetal serum \u00df2\u2010microglobulin and cystatin C are good markers for post\u2010natal renal function. However, in bilateral renal hyperechogenic enlargement, abnormal values are associated with poor post\u2010natal renal function, but normal values cannot preclude renal failure. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.866","type":"journal-article","created":{"date-parts":[[2004,5,21]],"date-time":"2004-05-21T13:01:35Z","timestamp":1085144495000},"page":"327-332","source":"Crossref","is-referenced-by-count":45,"title":["Fetal serum \u00df2\u2010microglobulin and cystatin C in the prediction of post\u2010natal renal function in bilateral hypoplasia and hyperechogenic enlarged kidneys"],"prefix":"10.1002","volume":"24","author":[{"given":"Fran\u00e7oise","family":"Muller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Dreux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Audibert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Jacques","family":"Chabaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Rousseau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"D'Herv\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Dumez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Ngo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Claire","family":"Gubler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Dommergues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.9208"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90928-1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.164.5.7717240"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.115283"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-199502000-00051"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(84)90359-4"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199811)18:11<1163::AID-PD408>3.0.CO;2-1"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199604)16:4<299::AID-PD844>3.0.CO;2-N"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90420-X"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00167.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1970.tb15534.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.181.1.1887022"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70235-7"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.57.2.123"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1681\/ASN.V3121863","article-title":"Characteristics 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