{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T22:26:38Z","timestamp":1775946398809,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Discovery"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Increasing evidence suggests that human bocavirus (HBoV) is associated with respiratory symptoms in the absence of other identifiable pathogens and may even precipitate severe lower respiratory tract infections. However, only a few studies of severe human bocavirus infections in pediatric patients have been reported. The aim of the current study was to collect and analyze clinical data from children diagnosed with mild pneumonia and severe pneumonia, with an emphasis on those testing positive for HBoV from June 2009 to June 2019. Among the 799 HBoV\u2010positive children included in the study, approximately 5.88% experienced severe pneumonia. Results revealed no significant differences between co\u2010detection and single detection of HBoV\u2010positive pneumonia in the severe and mild groups, supporting the pathogenicity of HBoV. A higher incidence of severe cases was observed in children lacking\n                    <jats:italic>Bacillus<\/jats:italic>\n                    Calmette\u2013Gu\u00e9rin (BCG) vaccination, or with congenital airway or bronchopulmonary dysplasia (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.046,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.017). Overall, these findings indicate that HBoV can be identified in respiratory samples from children with severe pneumonia, denoting its role as a viral pathogen in hospitalized children with this condition. Preterm birth, wheezing history of previous infection, pulmonary underlying diseases such as airway dysplasia or bronchopulmonary dysplasia, and viremia may be the risk factors for severe pneumonia with HBoV positive.\n                  <\/jats:p>","DOI":"10.1002\/pdi3.2523","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T03:04:52Z","timestamp":1738811092000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical characteristics and risk factors of severe bocavirus\u2010positive pneumonia in children and a literature review"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4423-6926","authenticated-orcid":false,"given":"Jing","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"},{"name":"Pediatric Research Institute of Children's Hospital of Chongqing Medical University  Chongqing China"},{"name":"Key Laboratory of Children's Important Organ Development and Diseases of Chongqing Municipal Health Commission  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"},{"name":"Pediatric Research Institute of Children's Hospital of Chongqing Medical University  Chongqing China"},{"name":"Key Laboratory of Children's Important Organ Development and Diseases of Chongqing Municipal Health Commission  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luo","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"},{"name":"Pediatric Research Institute of Children's Hospital of Chongqing Medical University  Chongqing China"},{"name":"Key Laboratory of Children's Important Organ Development and Diseases of Chongqing Municipal Health Commission  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enmei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504666102"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/595831"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(19)30057-4"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01533-17"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000514688"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605211027739"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23891"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2701.202061"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-021-01682-1"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2020.104453"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002354"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1149"},{"key":"e_1_2_11_14_1","first-page":"6","article-title":"State 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Guideline for diagnosis and treatment of community\u2010acquired pneumonia in Children (2019 version) (In Chinese)","volume":"12","author":"National Health Commission of the People\u2019s Republic of China","year":"2019","journal-title":"Chin J Clin Infect Dis"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12250-021-00437-0"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-022-04529-x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.14233"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-019-00324-5"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.06.014"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.047472-0"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-424"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-017-3694-5"},{"issue":"2","key":"e_1_2_11_23_1","article-title":"Prevalence and clinical characterization of bocavirus infection in a specialized children\u2019s hospital in Saudi Arabia","volume":"14","author":"Alkhalf H","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02140-06"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmy057"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91447-3"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S102819"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3126\/jnps.v42i1.38454"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.317055"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30920-X"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000509"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0337-y"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.07.012"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2010.07.016"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.949817"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix169"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.03132-20"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2019.09.003"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix352"}],"container-title":["Pediatric Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pdi3.2523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T19:17:29Z","timestamp":1767122249000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pdi3.2523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,6]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/pdi3.2523"],"URL":"https:\/\/doi.org\/10.1002\/pdi3.2523","archive":["Portico"],"relation":{},"ISSN":["2835-558X","2835-5598"],"issn-type":[{"value":"2835-558X","type":"print"},{"value":"2835-5598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,6]]},"assertion":[{"value":"2023-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2523"}}