{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:05:29Z","timestamp":1753869929227,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["cstc2020jcyj\u2010msxmX0253"],"award-info":[{"award-number":["cstc2020jcyj\u2010msxmX0253"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Discovery"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neonatal bacterial meningitis is serious and accounts for high morbidity and mortality in developing countries, but the duration of antimicrobial treatment is not well established. Cerebrospinal fluid (CSF) levels are important factors for diagnosing and monitoring the occurrence and development of bacterial meningitis. In this study, we aimed to compare the clinical characteristics and outcomes of neonatal bacterial meningitis with normal CSF and abnormal CSF at discharge. We enrolled neonates with bacterial meningitis who were admitted to the neonatology department of the Children's Hospital of Chongqing Medical University between August 1, 2019 and January 1, 2021. The children's clinical data, laboratory data, and outcomes were recorded and analyzed. Fifty\u2010five neonates met the inclusion criteria in our study. Other than CSF protein levels, there was no significant difference in clinical symptoms, blood levels (white blood cell [WBC] count, neutrophils, platelets, C\u2010reactive protein, and procalcitonin), CSF WBC counts at admission and discharge, duration of antibiotics, or hospital stays between the two groups (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). For the sequelae of bacterial meningitis, short\u2010 and long\u2010term complications also showed no statistically significant differences between the two groups. The duration of antimicrobial therapy in neonatal bacterial meningitis may depend on the clinical condition of the patient rather than the CSF levels. This study may improve the reasonable utilization of antibiotics in neonatal bacterial meningitis.<\/jats:p>","DOI":"10.1002\/pdi3.43","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T04:25:22Z","timestamp":1698899122000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The clinical condition rather than cerebrospinal fluid levels may guide the optimal duration of antimicrobial therapy among neonates with bacterial meningitis: A single\u2010center retrospective study"],"prefix":"10.1002","volume":"1","author":[{"given":"Ya","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Neonatology Children's Hospital of Chongqing Medical University  Chongqing China"},{"name":"Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"},{"name":"National Clinical Research Center for Child Health and Disorders  Chongqing China"},{"name":"China International Science and Technology Cooperation Base of Child Development and Critical Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Child Infection and Immunity  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Chongqing Red Cross Hospital  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Neonatology Children's Hospital of Chongqing Medical University  Chongqing China"},{"name":"Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"},{"name":"National Clinical Research Center for Child Health and Disorders  Chongqing China"},{"name":"China International Science and Technology Cooperation Base of Child Development and Critical Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Child Infection and Immunity  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8458-1660","authenticated-orcid":false,"given":"Hongdong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Emergency Children's Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-3147.165424"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00883-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu514"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005384"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2021.2004318"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-0476"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1982.03330010049030"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0238056"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3423"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.721439"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005335"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2018.76938"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2014.10.004"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-013-0057-x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0026-4946.17.05124-6"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1382-y"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60580-1"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmv002"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.1539"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.27"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181958755"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.5.1169"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:EJEP.0000017828.13995.76"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-1126"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.84.5.450d"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1086\/425368"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00012"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141620"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/49.3.410"}],"container-title":["Pediatric 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