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Regardless of the type of oxygen therapy used, bedside clinicians frequently adjust the FiO<jats:sub>2<\/jats:sub> level. Automatic oxygen management is progressively developing as a viable alternative to these corrections. The purpose of this study is to compare the efficacy and safety of automated versus manual oxygen control in preterm infants receiving respiratory support. All the studies were searched from PubMed, Web of Science, Cochrane Library, Embase, CNKI, Wan Fang, VIP, and CBM on 7 May 2022. PICOS criteria were as follows: (P) participants were preterm infants receiving respiratory support; (I) intervention was automatic oxygen control; (C) comparator mode was manual oxygen control; (O) the primary outcome was the percentage of time within the target pulse oxygen saturation range; (S) randomized clinical trials. Sixteen studies were included in this meta\u2010analysis. The results showed that automated oxygen control can increase the percentage of time spent within the target SpO<jats:sub>2<\/jats:sub> range while reducing the percentage of time spent above the target SpO<jats:sub>2<\/jats:sub> range, the percentage time of hypoxemia, and manual FiO<jats:sub>2<\/jats:sub> adjustments\/hour. No significant difference was observed in the percentage of time spent below the target SpO<jats:sub>2<\/jats:sub> range, incidence of bradycardia, and the mean SpO<jats:sub>2<\/jats:sub> or mean FiO<jats:sub>2<\/jats:sub> level. Automatic oxygen control can improve preterm infants' oxygen saturation, reduce periods of hypoxemia and the percentage of time spent above the target SpO<jats:sub>2<\/jats:sub> range, and ease the workload of medical staff without affecting the mean FiO<jats:sub>2<\/jats:sub> and mean SpO<jats:sub>2<\/jats:sub> levels.<\/jats:p>","DOI":"10.1002\/pdi3.57","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T14:49:51Z","timestamp":1716389391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The effectiveness of automated adjustment of inspired oxygen in preterm infants receiving respiratory support compared with manual: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4651-4666","authenticated-orcid":false,"given":"Yihan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neonatology Children\u2019s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity Chongqing Key Laboratory of Pediatrics  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxuan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Neonatology Children\u2019s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity Chongqing Key Laboratory of Pediatrics  Chongqing 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