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On the other hand, highly malignant NBs can invade the surrounding blood vessels and organs and metastasize to distant bone, bone marrow, and lymph nodes in the early stages of the disease. Based on differential affinities to insulin growth factors (IGFs), insulin growth factor binding proteins (IGFBPs) are classified into two groups: IGF binding proteins (IGFBP1\u20106) with high\u2010affinity and IGF low\u2010affinity binding proteins, such as IGFBP\u2010related proteins (IGFBP rP1\u201010). IGFBP are crucial regulators of the bioavailability and function of IGF in metabolic signaling and as modulators of IGF signaling, and their role in NB is gaining increasing attention. In this study, we investigate the involvement of IGFBP family members in the growth and differentiation of NB cells, as well as the potential of IGFBPs as prognostic biomarkers and therapeutic targets for human NB.<\/jats:p>","DOI":"10.1002\/pdi3.68","type":"journal-article","created":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T13:48:37Z","timestamp":1717854517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Regulatory roles of insulin growth factor binding protein family in neuroblastoma cell proliferation and differentiation: Potential prognostic biomarkers and therapeutic targets for neuroblastoma"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2752-1650","authenticated-orcid":false,"given":"Kai","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgical Oncology Children\u2019s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LinYu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgical Oncology Children\u2019s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgical Oncology Children\u2019s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of 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