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Airway mucus hypersecretion is an important common pathophysiological and clinical manifestation of these diseases and is closely associated with adverse clinical outcomes. At present, the management of airway mucus hypersecretion lacks a viable clinical intervention. However, the revelation that the EGFR signaling pathway acts as a convergent intracellular pathway for many inflammatory mediators indicates that it exhibits the greatest potential for inhibiting excessive mucus production. This review provides a comprehensive overview of the role of EGFR in airway mucus hypersecretion and the therapeutic progress of targeting it, intending to improve clinicians' understanding of the mechanism and offer insights and recommendations for developing novel pharmaceutical interventions to regulate mucus secretion.<\/jats:p>","DOI":"10.1002\/pdi3.70007","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T06:40:27Z","timestamp":1746859227000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Recent Progress in Treating Airway Mucus Hypersecretion by Targeting the Epidermal Growth Factor Receptor Signaling Pathway"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6072-1489","authenticated-orcid":false,"given":"Yuanyuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Pediatrics Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuping","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Pediatrics Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Pediatrics Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2864-505X","authenticated-orcid":false,"given":"Yu","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Pediatrics Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enmei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Pediatrics Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,10]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12712"},{"key":"e_1_2_13_3_1","article-title":"Mucus Hypersecretion in Chronic Obstructive Pulmonary Disease and Its Treatment","author":"Shah B. 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