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Real\u2010world use of ustekinumab (UST), vedolizumab (VDZ), upadacitinib (UPA), tofacitinib, and ozanimod in the adult population could prove positive outcomes in the pediatric population. Established off\u2010label therapies inch closer to comparable safety, efficacy, and outcomes in pediatric IBD use. Outcomes and use of newer biologic therapies in patients with pediatric IBD have improved with increased rates of steroid\u2010free clinical remission (SFCR). Novel therapies, including Janus kinase (JAK) inhibitors and sphingosine\u20101\u2010phosphate receptor (S1Pr) modulators, require further studies but could also prove effective.<\/jats:p>","DOI":"10.1002\/pdi3.70011","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T05:17:12Z","timestamp":1750223832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Review of the Current State of Off\u2010Label Therapies for Pediatric Inflammatory Bowel Disease"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8879-9062","authenticated-orcid":false,"given":"Yassin","family":"EL\u2010Najjar","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Texas Southwestern Medical Center  Dallas Texas 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