{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:36:59Z","timestamp":1792841819078,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Discovery"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder characterized by abdominal pain and changes in bowel habits. Cinnamaldehyde (CA) possesses anti\u2010inflammatory, antibacterial, and digestive\u2010regulatory properties. However, its therapeutic potential for IBS and mechanisms are not understood. We employed network pharmacology to identify potential targets and pathways of CA against IBS. Core targets were validated through molecular docking, and further verified in an IBS rat model induced by neonatal maternal separation (NMS) and water avoidance stress (WAS). Network pharmacology identified 139 potential targets of CA related to IBS. Gene Ontology (GO) enrichment analysis highlighted key biological processes, cellular components, and molecular functions. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis suggested involvement of pathways such as nitrogen metabolism, tyrosine metabolism, and cocaine addiction. A protein\u2013protein interaction (PPI) network revealed 11 major targets, and molecular docking demonstrated strong binding affinities between CA and several targets, particularly\n                    <jats:italic>MAOB<\/jats:italic>\n                    ,\n                    <jats:italic>PARP1<\/jats:italic>\n                    ,\n                    <jats:italic>HDAC1<\/jats:italic>\n                    ,\n                    <jats:italic>JAK2<\/jats:italic>\n                    , and\n                    <jats:italic>MMP2<\/jats:italic>\n                    . Animal experiments confirmed that CA significantly reduces\n                    <jats:italic>MAOB<\/jats:italic>\n                    , as well as TNF\u2010\u03b1, IL\u20106, and IL\u20101\u03b2 levels, thereby alleviating visceral hypersensitivity and anxiety and depression\u2010like behaviors in IBS rats. These findings provide a scientific basis for developing CA as a potential natural therapeutic agent for IBS.\n                  <\/jats:p>","DOI":"10.1002\/pdi3.70017","type":"journal-article","created":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:29:51Z","timestamp":1759681791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1883-7354","authenticated-orcid":false,"given":"Qingyang","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine Children's Hospital of Chongqing Medical University  Chongqing China"},{"name":"Growth, Development, and Mental Health of Children and Adolescence Center Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Pediatric Research Institute National Clinical Research Center for Child Health and Disorders Children\u2019s Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Growth, Development, and Mental Health of Children and Adolescence Center Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Pediatric Research Institute National Clinical Research Center for Child Health and Disorders Children\u2019s Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfang","family":"Dai","sequence":"additional","affiliation":[{"name":"Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangdong Provincial Clinical Research Center for Child Health  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayan","family":"Pang","sequence":"additional","affiliation":[{"name":"Growth, Development, and Mental Health of Children and Adolescence Center Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Pediatric Research Institute National Clinical Research Center for Child Health and Disorders Children\u2019s Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3411-7923","authenticated-orcid":false,"given":"Zhifang","family":"Dong","sequence":"additional","affiliation":[{"name":"Growth, Development, and Mental Health of Children and Adolescence Center Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key 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